Sign in or Register   Sign in or Register
  |  

Mouse Anti-FOXD1 Recombinant Antibody (CBXF-1772) (CBMAB-F3307-CQ)

This product is a mouse antibody that recognizes FOXD1. The antibody CBXF-1772 can be used for immunoassay techniques such as: WB, IP, ELISA.
See all FOXD1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-1772
Antibody Isotype
IgG2b, κ
Application
WB, IP, ELISA

Basic Information

Immunogen
Partial recombinant corresponding to aa1-91 from human FOXD1 (NP_004463) with GST tag
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
forkhead box D1
Introduction
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. Studies of the orthologous mouse protein indicate that it functions in kidney development by promoting nephron progenitor differentiation, and it also functions in the development of the retina and optic chiasm. It may also regulate inflammatory reactions and prevent autoimmunity.
Entrez Gene ID
2297
UniProt ID
Q16676
Alternative Names
Forkhead Box D1; Forkhead-Related Transcription Factor 4; Forkhead-Related Protein FKHL8; FREAC-4; FREAC4; FKHL8;
Function
Transcription factor involved in regulation of gene expression in a variety of processes, including formation of positional identity in the developing retina, regionalization of the optic chiasm, morphogenesis of the kidney, and neuralization of ectodermal cells (By similarity).

Involved in transcriptional activation of PGF and C3 genes (PubMed:27805902).
Biological Process
Anatomical structure morphogenesis Source: GO_Central
Axon guidance Source: Ensembl
Cell differentiation Source: GO_Central
Dichotomous subdivision of terminal units involved in ureteric bud branching Source: UniProtKB
Luteinizing hormone secretion Source: Ensembl
Metanephric capsule development Source: UniProtKB
Metanephric capsule specification Source: UniProtKB
Metanephric nephron development Source: Ensembl
Negative regulation of transcription, DNA-templated Source: UniProtKB
Nephrogenic mesenchyme development Source: Ensembl
Positive regulation of BMP signaling pathway Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of kidney development Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus

Ma, Y., Han, J., & Luo, X. (2023). FOXD1‐AS1 upregulates FOXD1 to promote oral squamous cell carcinoma progression. Oral Diseases, 29(2), 604-614.

Wu, Q., Ma, J., Wei, J., Meng, W., Wang, Y., & Shi, M. (2021). FOXD1‐AS1 regulates FOXD1 translation and promotes gastric cancer progression and chemoresistance by activating the PI3K/AKT/mTOR pathway. Molecular oncology, 15(1), 299-316.

Gao, Y. F., Liu, J. Y., Mao, X. Y., He, Z. W., Zhu, T., Wang, Z. B., ... & Liu, Z. Q. (2020). LncRNA FOXD1‐AS1 acts as a potential oncogenic biomarker in glioma. CNS Neuroscience & Therapeutics, 26(1), 66-75.

Chen, C., Xu, Z. Q., Zong, Y. P., Ou, B. C., Shen, X. H., Feng, H., ... & Lu, A. G. (2019). CXCL5 induces tumor angiogenesis via enhancing the expression of FOXD1 mediated by the AKT/NF-κB pathway in colorectal cancer. Cell death & disease, 10(3), 178.

Fu, L., Hu, Y., Song, M., Liu, Z., Zhang, W., Yu, F. X., ... & Liu, G. H. (2019). Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis. PLoS biology, 17(4), e3000201.

Li, C. H., Chang, Y. C., Hsiao, M., & Liang, S. M. (2019). FOXD1 and Gal-3 form a positive regulatory loop to regulate lung cancer aggressiveness. Cancers, 11(12), 1897.

Quintero-Ronderos, P., & Laissue, P. (2018). The multisystemic functions of FOXD1 in development and disease. Journal of Molecular Medicine, 96, 725-739.

Li, D., Fan, S., Yu, F., Zhu, X., Song, Y., Ye, M., ... & Lv, Z. (2018). FOXD1 promotes cell growth and metastasis by activation of vimentin in NSCLC. Cellular physiology and biochemistry, 51(6), 2716-2731.

Shanmughapriya, S., Tomar, D., Dong, Z., Slovik, K. J., Nemani, N., Natarajaseenivasan, K., ... & Madesh, M. (2018). FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation. Nature communications, 9(1), 3449.

Tao, J., Cong, H., Wang, H., Zhang, D., Liu, C., Chu, H., ... & Wang, K. (2018). MiR-30a-5p inhibits osteosarcoma cell proliferation and migration by targeting FOXD1. Biochemical and Biophysical Research Communications, 503(2), 1092-1097.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-FOXD1 Recombinant Antibody (CBXF-1772)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare