Mouse Anti-FOXD1 Recombinant Antibody (CBXF-1772) (CBMAB-F3307-CQ)

Name: Mouse Anti-FOXD1 Recombinant Antibody (CBXF-1772)
SKU: CBMAB-F3307-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-1772

Application

WB, IP, ELISA

Immunogen

Partial recombinant corresponding to aa1-91 from human FOXD1 (NP_004463) with GST tag

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

forkhead box D1

Introduction

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. Studies of the orthologous mouse protein indicate that it functions in kidney development by promoting nephron progenitor differentiation, and it also functions in the development of the retina and optic chiasm. It may also regulate inflammatory reactions and prevent autoimmunity.

Entrez Gene ID

2297

UniProt ID

Q16676

Alternative Names

Forkhead Box D1; Forkhead-Related Transcription Factor 4; Forkhead-Related Protein FKHL8; FREAC-4; FREAC4; FKHL8;

Function

Transcription factor involved in regulation of gene expression in a variety of processes, including formation of positional identity in the developing retina, regionalization of the optic chiasm, morphogenesis of the kidney, and neuralization of ectodermal cells (By similarity).

Involved in transcriptional activation of PGF and C3 genes (PubMed:27805902).

Biological Process

Anatomical structure morphogenesis Source: GO_Central
Axon guidance Source: Ensembl
Cell differentiation Source: GO_Central
Dichotomous subdivision of terminal units involved in ureteric bud branching Source: UniProtKB
Luteinizing hormone secretion Source: Ensembl
Metanephric capsule development Source: UniProtKB
Metanephric capsule specification Source: UniProtKB
Metanephric nephron development Source: Ensembl
Negative regulation of transcription, DNA-templated Source: UniProtKB
Nephrogenic mesenchyme development Source: Ensembl
Positive regulation of BMP signaling pathway Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of kidney development Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

Ma, Y., Han, J., & Luo, X. (2023). FOXD1‐AS1 upregulates FOXD1 to promote oral squamous cell carcinoma progression. Oral Diseases, 29(2), 604-614.

Wu, Q., Ma, J., Wei, J., Meng, W., Wang, Y., & Shi, M. (2021). FOXD1‐AS1 regulates FOXD1 translation and promotes gastric cancer progression and chemoresistance by activating the PI3K/AKT/mTOR pathway. Molecular oncology, 15(1), 299-316.

Gao, Y. F., Liu, J. Y., Mao, X. Y., He, Z. W., Zhu, T., Wang, Z. B., ... & Liu, Z. Q. (2020). LncRNA FOXD1‐AS1 acts as a potential oncogenic biomarker in glioma. CNS Neuroscience & Therapeutics, 26(1), 66-75.

Chen, C., Xu, Z. Q., Zong, Y. P., Ou, B. C., Shen, X. H., Feng, H., ... & Lu, A. G. (2019). CXCL5 induces tumor angiogenesis via enhancing the expression of FOXD1 mediated by the AKT/NF-κB pathway in colorectal cancer. Cell death & disease, 10(3), 178.

Fu, L., Hu, Y., Song, M., Liu, Z., Zhang, W., Yu, F. X., ... & Liu, G. H. (2019). Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis. PLoS biology, 17(4), e3000201.

Li, C. H., Chang, Y. C., Hsiao, M., & Liang, S. M. (2019). FOXD1 and Gal-3 form a positive regulatory loop to regulate lung cancer aggressiveness. Cancers, 11(12), 1897.

Quintero-Ronderos, P., & Laissue, P. (2018). The multisystemic functions of FOXD1 in development and disease. Journal of Molecular Medicine, 96, 725-739.

Li, D., Fan, S., Yu, F., Zhu, X., Song, Y., Ye, M., ... & Lv, Z. (2018). FOXD1 promotes cell growth and metastasis by activation of vimentin in NSCLC. Cellular physiology and biochemistry, 51(6), 2716-2731.

Shanmughapriya, S., Tomar, D., Dong, Z., Slovik, K. J., Nemani, N., Natarajaseenivasan, K., ... & Madesh, M. (2018). FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation. Nature communications, 9(1), 3449.

Tao, J., Cong, H., Wang, H., Zhang, D., Liu, C., Chu, H., ... & Wang, K. (2018). MiR-30a-5p inhibits osteosarcoma cell proliferation and migration by targeting FOXD1. Biochemical and Biophysical Research Communications, 503(2), 1092-1097.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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For research use only. Not intended for any clinical use.

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