Rat Anti-FZD9 Recombinant Antibody (CBXF-2695) (CBMAB-F3097-CQ)

Name: Rat Anti-FZD9 Recombinant Antibody (CBXF-2695)
SKU: CBMAB-F3097-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rat

Clone

CBXF-2695

Application

Immunogen

Sf 21-derived recombinant mouse Frizzled-9, Ala23-Asp186 (predicted), Accession # Q9R216

Specificity

Mouse

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

Lyophilized from a 0.2 μm filtered solution in PBS with trehalose

Concentration

LYOPH

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Frizzled Class Receptor 9

Introduction

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.

Entrez Gene ID

14371

UniProt ID

Q9R216

Alternative Names

Frizzled Class Receptor 9; Frizzled 9, Seven Transmembrane Spanning Receptor; Frizzled Family Receptor 9; Fz-9; FzE6; FZD3; HFz9;

Function

Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity).

Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity).

May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (PubMed:27509850).

During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity).

Biological Process

B cell differentiation Source: Ensembl
Bone regeneration Source: UniProtKB
Canonical Wnt signaling pathway Source: GO_Central
Learning or memory Source: Ensembl
Negative regulation of mitochondrial depolarization Source: UniProtKB
Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: UniProtKB
Negative regulation of necroptotic process Source: UniProtKB
Negative regulation of neuron apoptotic process Source: UniProtKB
Negative regulation of skeletal muscle acetylcholine-gated channel clustering Source: UniProtKB
Nervous system development Source: ProtInc
Neuroblast proliferation Source: Ensembl
Ossification Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of bone mineralization Source: UniProtKB
Positive regulation of canonical Wnt signaling pathway Source: UniProtKB
Positive regulation of neural precursor cell proliferation Source: UniProtKB
Postsynapse organization Source: Ensembl
Regulation of cell cycle Source: UniProtKB
Regulation of cytosolic calcium ion concentration Source: UniProtKB
Regulation of postsynaptic cytosolic calcium ion concentration Source: Ensembl
Regulation of skeletal muscle acetylcholine-gated channel clustering Source: UniProtKB
Release of cytochrome c from mitochondria Source: UniProtKB

Cellular Location

Cell membrane. Relocalizes DVL1 to the cell membrane leading to phosphorylation of DVL1 and AXIN1 relocalization to the cell membrane.

Topology

Extracellular: 23-229
Helical: 230-250
Cytoplasmic: 251-266
Helical: 267-287
Extracellular: 288-315
Helical: 316-336
Cytoplasmic: 337-355
Helical: 356-376
Extracellular: 377-400
Helical: 401-421
Cytoplasmic: 422-447
Helical: 448-468
Extracellular: 469-508
Helical: 509-529
Cytoplasmic: 530-591

PTM

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Rabbit Anti-FZD9 Recombinant Antibody (EG1260) (CAT#: CBMAB-EN1523-LY)

Mouse Anti-FZD9 Recombinant Antibody (W3C4E11) (CAT#: CBMAB-C11617-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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