FZD9

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.

Frizzled Class Receptor 9

Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity).

Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity).

May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (PubMed:27509850).

During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity).

B cell differentiation Source: Ensembl
Bone regeneration Source: UniProtKB
Canonical Wnt signaling pathway Source: GO_Central
Learning or memory Source: Ensembl
Negative regulation of mitochondrial depolarization Source: UniProtKB
Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: UniProtKB
Negative regulation of necroptotic process Source: UniProtKB
Negative regulation of neuron apoptotic process Source: UniProtKB
Negative regulation of skeletal muscle acetylcholine-gated channel clustering Source: UniProtKB
Nervous system development Source: ProtInc
Neuroblast proliferation Source: Ensembl
Ossification Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of bone mineralization Source: UniProtKB
Positive regulation of canonical Wnt signaling pathway Source: UniProtKB
Positive regulation of neural precursor cell proliferation Source: UniProtKB
Postsynapse organization Source: Ensembl
Regulation of cell cycle Source: UniProtKB
Regulation of cytosolic calcium ion concentration Source: UniProtKB
Regulation of postsynaptic cytosolic calcium ion concentration Source: Ensembl
Regulation of skeletal muscle acetylcholine-gated channel clustering Source: UniProtKB
Release of cytochrome c from mitochondria Source: UniProtKB

Cell membrane. Relocalizes DVL1 to the cell membrane leading to phosphorylation of DVL1 and AXIN1 relocalization to the cell membrane.

Extracellular: 23-229
Helical: 230-250
Cytoplasmic: 251-266
Helical: 267-287
Extracellular: 288-315
Helical: 316-336
Cytoplasmic: 337-355
Helical: 356-376
Extracellular: 377-400
Helical: 401-421
Cytoplasmic: 422-447
Helical: 448-468
Extracellular: 469-508
Helical: 509-529
Cytoplasmic: 530-591

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.