Rabbit Anti-GPR173 Recombinant Antibody (EG1392) (CBMAB-EN1671-LY)

The product is antibody recognizes GPR173. The antibody EG1392 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:40000.
See all GPR173 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse, Rat

Clone

EG1392

Antibody Isotype

IgG

Application

WB: 1:500~1:1000 ELISA: 1:40000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human GPR173.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

G protein-coupled receptor 173

Introduction

This gene encodes a member of the G-protein coupled receptor 1 family. This protein contains 7 transmembrane domains and conserved cysteine residues.

Entrez Gene ID

Human	54328
Mouse	70771
Rat	64021

UniProt ID

Human	Q9NS66
Mouse	Q6PI62
Rat	Q9JJH2

Alternative Names

SREB3

Function

Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20 (By similarity).

It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland (By similarity).

In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth (PubMed:30933929).

Biological Process

Signal transduction Source: ProtInc

Cellular Location

Cell membrane

Topology

Extracellular: 1-26
Helical: 27-47
Cytoplasmic: 48-59
Helical: 60-80
Extracellular: 81-97
Helical: 98-118
Cytoplasmic: 119-139
Helical: 140-160
Extracellular: 161-188
Helical: 189-209
Cytoplasmic: 210-287
Helical: 288-308
Extracellular: 309-322
Helical: 323-343
Cytoplasmic: 344-373

References

Pillaiyar, T., Rosato, F., Wozniak, M., Blavier, J., Charles, M., Laschet, C., ... & Hanson, J. (2021). Structure-activity relationships of agonists for the orphan G protein-coupled receptor GPR27. European Journal of Medicinal Chemistry, 225, 113777.

Breton, T. S., Sampson, W. G., Clifford, B., Phaneuf, A. M., Smidt, I., True, T., ... & DiMaggio, M. A. (2021). Characterization of the G protein-coupled receptor family SREB across fish evolution. Scientific Reports, 11(1), 1-17.

Watkins, L. R., & Orlandi, C. (2020). Orphan G protein coupled receptors in affective disorders. Genes, 11(6), 694.

Laschet, C., Dupuis, N., & Hanson, J. (2018). The G protein-coupled receptors deorphanization landscape. Biochemical Pharmacology, 153, 62-74.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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