GPR173

This gene encodes a member of the G-protein coupled receptor 1 family. This protein contains 7 transmembrane domains and conserved cysteine residues.

G protein-coupled receptor 173

Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20 (By similarity).

It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland (By similarity).

In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth (PubMed:30933929).

Signal transduction Source: ProtInc

Cell membrane

Extracellular: 1-26
Helical: 27-47
Cytoplasmic: 48-59
Helical: 60-80
Extracellular: 81-97
Helical: 98-118
Cytoplasmic: 119-139
Helical: 140-160
Extracellular: 161-188
Helical: 189-209
Cytoplasmic: 210-287
Helical: 288-308
Extracellular: 309-322
Helical: 323-343
Cytoplasmic: 344-373