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Rat Anti-GSR Recombinant Antibody (AP-MAB0866) (CBMAB-G5314-LY)

This product is antibody recognizes GSR. The antibody AP-MAB0866 immunoassay techniques such as: IHC-P, IHC-Fr, FC.
See all GSR antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
AP-MAB0866
Antibody Isotype
IgG2
Application
IHC-P, IHC-Fr, FC

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
glutathione reductase
Introduction
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]
Entrez Gene ID
UniProt ID
Alternative Names
AI325518; D8Ertd238e; Gr-1; Gr1
Function
Maintains high levels of reduced glutathione in the cytosol.
Biological Process
Cell redox homeostasis Source: GO_Central
Cellular response to oxidative stress Source: GO_Central
Glutathione metabolic process Source: GO_Central
Cellular Location
Isoform Mitochondrial: Mitochondrion
Isoform Cytoplasmic: Cytoplasm
Involvement in disease
Hemolytic anemia due to glutathione reductase deficiency (HAGRD):
An autosomal recessive disease characterized by hemolytic anemia and impaired activity of glutathione reductase. Patients experience hemolytic anemia in response to oxidative stress or ingestion of fava beans.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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