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Rabbit Anti-GYS1 Recombinant Antibody (7H2215B1) (CBMAB-G5886-LY)

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Basic Information

Host Animal
Rabbit
Clone
7H2215B1
Application
ELISA, IHC, IP, WB
Immunogen
Synthetic peptide derived from the sequence of human glycogen synthase
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol, 0.1mg/ml BSA
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Glycogen Synthase 1
Introduction
The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Entrez Gene ID
Human2997
Mouse14936
Rat690987
UniProt ID
HumanP13807
MouseQ9Z1E4
RatA2RRU1
Alternative Names
Glycogen Synthase 1; Glycogen Synthase 1 (Muscle); EC 2.4.1.11; GYS; Glycogen [Starch] Synthase; Muscle; GSY;
Function
Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
Biological Process
Glycogen biosynthetic process Source: UniProtKB
Heart development Source: Ensembl
Cellular Location
Cytosol; Cytoplasm; Inclusion body; Membrane
Involvement in disease
Muscle glycogen storage disease 0 (GSD0b):
Metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood. The role of muscle glycogen is to provide critical energy during bursts of activity and sustained muscle work.
PTM
Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B (By similarity). Phosphorylated at Ser-641 by DYRK2, leading to inactivation (By similarity). Phosphorylated at Ser-641 by PASK, leading to inactivation; phosphorylation by PASK is inhibited by glycogen. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme.

de Heer, E. C., Zois, C. E., Bridges, E., van der Vegt, B., Sheldon, H., Veldman, W. A., ... & Jalving, M. (2023). Glycogen synthase 1 targeting reveals a metabolic vulnerability in triple-negative breast cancer. Journal of Experimental & Clinical Cancer Research, 42(1), 1-14.

Fastman, N. M., Liu, Y., Ramanan, V., Merritt, H., Ambing, E., DePaoli-Roach, A. A., ... & Tzitzilonis, C. (2022). The structural mechanism of human glycogen synthesis by the GYS1-GYG1 complex. Cell Reports, 40(1).

Ahonen, S., Nitschke, S., Grossman, T. R., Kordasiewicz, H., Wang, P., Zhao, X., ... & Minassian, B. A. (2021). Gys1 antisense therapy rescues neuropathological bases of murine Lafora disease. Brain, 144(10), 2985-2993.

Nitschke, S., Chown, E. E., Zhao, X., Gabrielian, S., Petković, S., Guisso, D. R., ... & Minassian, B. A. (2021). An inducible glycogen synthase-1 knockout halts but does not reverse Lafora disease progression in mice. Journal of Biological Chemistry, 296.

Santamans, A. M., Montalvo-Romeral, V., Mora, A., Lopez, J. A., González-Romero, F., Jimenez-Blasco, D., ... & Sabio, G. (2021). p38γ and p38δ regulate postnatal cardiac metabolism through glycogen synthase 1. PLoS biology, 19(11), e3001447.

Chen, S. L., Huang, Q. S., Huang, Y. H., Yang, X., Yang, M. M., He, Y. F., ... & Yun, J. P. (2020). GYS1 induces glycogen accumulation and promotes tumor progression via the NF-κB pathway in Clear Cell Renal Carcinoma. Theranostics, 10(20), 9186.

Shi, M., Wang, J., Xiao, Y., Wang, C., Qiu, Q., Lao, M., ... & Xu, H. (2018). Glycogen metabolism and rheumatoid arthritis: the role of glycogen synthase 1 in regulation of synovial inflammation via blocking AMP-activated protein kinase activation. Frontiers in immunology, 9, 1714.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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