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GYS1

The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Full Name
Glycogen Synthase 1
Function
Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
Biological Process
Glycogen biosynthetic process Source: UniProtKB
Heart development Source: Ensembl
Cellular Location
Cytosol; Cytoplasm; Inclusion body; Membrane
Involvement in disease
Muscle glycogen storage disease 0 (GSD0b):
Metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood. The role of muscle glycogen is to provide critical energy during bursts of activity and sustained muscle work.
PTM
Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B (By similarity). Phosphorylated at Ser-641 by DYRK2, leading to inactivation (By similarity). Phosphorylated at Ser-641 by PASK, leading to inactivation; phosphorylation by PASK is inhibited by glycogen. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme.

Anti-GYS1 antibodies

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Target: GYS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 15B1
Application*: WB
Target: GYS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3A7
Application*: E, WB
Target: GYS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 7i21
Application*: F
Target: GYS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: J.18.5
Application*: P, IP, WB
Target: GYS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBLG1-2193
Application*: WB
Target: GYS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2194
Application*: E, WB
Target: GYS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Application*: WB, P, IF/IC, IP
Target: GYS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0552
Application*: E, WB
Target: GYS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-3054
Application*: IC/IF
Target: GYS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: CBLG1-3055
Application*: WB
Target: GYS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B364
Application*: E, F
Target: GYS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 7H2215B1
Application*: E, IH, IP, WB
Target: GYS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBLG1-3057
Application*: P, WB
Target: GYS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2192
Application*: E, F
Target: GYS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2195
Application*: IC, IF, IH, IP, WB
Target: GYS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2196
Application*: E, F
Target: GYS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBNH-142
Application*: E, WB, IF
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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