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Mouse Anti-HOXB9 Recombinant Antibody (3C8) (CBMAB-A4050-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3C8
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
HOXB9 (NP_076922.1, 65 a.a. ~ 163 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
homeobox B9
Introduction
This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer. [provided by RefSeq]
Entrez Gene ID
3219
UniProt ID
P17482
Alternative Names
HOX-2.5; HOX2; HOX2E
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Biological Process
Anterior/posterior pattern specification Source: GO_Central
Cell chemotaxis Source: UniProtKB
Embryonic skeletal system morphogenesis Source: GO_Central
Mammary gland development Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Proximal/distal pattern formation Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Transcription, DNA-templated Source: InterPro
Cellular Location
Nucleus
More Infomation

Wang, T., Guo, H., Li, Q., Wu, W., Yu, M., Zhang, L., ... & Zhan, J. (2022). The AMPK-HOXB9-KRAS axis regulates lung adenocarcinoma growth in response to cellular energy alterations. Cell Reports, 40(8).

Yao, Y., Liu, C., Wang, B., Guan, X., Fang, L., Zhan, F., ... & Zhang, Y. (2022). HOXB9 blocks cell cycle progression to inhibit pancreatic cancer cell proliferation through the DNMT1/RBL2/c-Myc axis. Cancer Letters, 533, 215595.

Martinou, E., Falgari, G., Bagwan, I., & Angelidi, A. M. (2021). A systematic review on HOX genes as potential biomarkers in colorectal cancer: an emerging role of HOXB9. International journal of molecular sciences, 22(24), 13429.

Zheng, H., Li, C., Li, Z., Zhu, K., Bao, H., Xiong, J., & Liang, P. (2021). HOXB9 enhances the ability of lung cancer cells to penetrate the blood-brain barrier. Aging (Albany NY), 13(4), 4999.

Zhang, L., Wu, Q., He, C., Liang, D., Yi, Q., Shi, J., ... & Chang, Q. (2019). HOXB9 inhibits proliferation in gastric carcinoma cells via suppression of phosphorylated-Akt and NF-κB-dependent Snail expression. Digestive and Liver Disease, 51(1), 157-165.

Kato, F., Wada, N., Hayashida, T., Fukuda, K., Nakamura, R., Takahashi, T., ... & Kitagawa, Y. (2019). Experimental and clinicopathological analysis of HOXB9 in gastric cancer. Oncology letters, 17(3), 3097-3102.

Xiong, H., Xiao, H., Luo, C., Chen, L., Liu, X., Hu, Z., ... & Wang, K. (2019). GRP78 activates the Wnt/HOXB9 pathway to promote invasion and metastasis of hepatocellular carcinoma by chaperoning LRP6. Experimental Cell Research, 383(1), 111493.

Song, J., Wang, T., Xu, W., Wang, P., Wan, J., Wang, Y., ... & Zhang, H. (2018). HOXB9 acetylation at K27 is responsible for its suppression of colon cancer progression. Cancer Letters, 426, 63-72.

Wan, J., Liu, H., Feng, Q., Liu, J., & Ming, L. (2018). HOXB9 promotes endometrial cancer progression by targeting E2F3. Cell death & disease, 9(5), 509.

Lin, J., Zhang, D., Fan, Y., Chao, Y., Chang, J., Li, N., ... & Han, C. (2018). Regulation of cancer stem cell self-renewal by HOXB9 antagonizes endoplasmic reticulum stress-induced melanoma cell apoptosis via the miR-765–FOXA2 axis. Journal of Investigative Dermatology, 138(7), 1609-1619.

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For research use only. Not intended for any clinical use.

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