Mouse Anti-HOXB9 Recombinant Antibody (3C8) (CBMAB-A4050-LY)

Name: Mouse Anti-HOXB9 Recombinant Antibody (3C8)
SKU: CBMAB-A4050-LY
Rating: 5 (1 reviews)

See all HOXB9 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3C8

Application

WB, ELISA

Immunogen

HOXB9 (NP_076922.1, 65 a.a. ~ 163 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

homeobox B9

Introduction

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer. [provided by RefSeq]

Entrez Gene ID

3219

UniProt ID

P17482

Alternative Names

HOX-2.5; HOX2; HOX2E

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Biological Process

Anterior/posterior pattern specification Source: GO_Central
Cell chemotaxis Source: UniProtKB
Embryonic skeletal system morphogenesis Source: GO_Central
Mammary gland development Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Proximal/distal pattern formation Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Transcription, DNA-templated Source: InterPro

Cellular Location

Nucleus

Wang, T., Guo, H., Li, Q., Wu, W., Yu, M., Zhang, L., ... & Zhan, J. (2022). The AMPK-HOXB9-KRAS axis regulates lung adenocarcinoma growth in response to cellular energy alterations. Cell Reports, 40(8).

Yao, Y., Liu, C., Wang, B., Guan, X., Fang, L., Zhan, F., ... & Zhang, Y. (2022). HOXB9 blocks cell cycle progression to inhibit pancreatic cancer cell proliferation through the DNMT1/RBL2/c-Myc axis. Cancer Letters, 533, 215595.

Martinou, E., Falgari, G., Bagwan, I., & Angelidi, A. M. (2021). A systematic review on HOX genes as potential biomarkers in colorectal cancer: an emerging role of HOXB9. International journal of molecular sciences, 22(24), 13429.

Zheng, H., Li, C., Li, Z., Zhu, K., Bao, H., Xiong, J., & Liang, P. (2021). HOXB9 enhances the ability of lung cancer cells to penetrate the blood-brain barrier. Aging (Albany NY), 13(4), 4999.

Zhang, L., Wu, Q., He, C., Liang, D., Yi, Q., Shi, J., ... & Chang, Q. (2019). HOXB9 inhibits proliferation in gastric carcinoma cells via suppression of phosphorylated-Akt and NF-κB-dependent Snail expression. Digestive and Liver Disease, 51(1), 157-165.

Kato, F., Wada, N., Hayashida, T., Fukuda, K., Nakamura, R., Takahashi, T., ... & Kitagawa, Y. (2019). Experimental and clinicopathological analysis of HOXB9 in gastric cancer. Oncology letters, 17(3), 3097-3102.

Xiong, H., Xiao, H., Luo, C., Chen, L., Liu, X., Hu, Z., ... & Wang, K. (2019). GRP78 activates the Wnt/HOXB9 pathway to promote invasion and metastasis of hepatocellular carcinoma by chaperoning LRP6. Experimental Cell Research, 383(1), 111493.

Song, J., Wang, T., Xu, W., Wang, P., Wan, J., Wang, Y., ... & Zhang, H. (2018). HOXB9 acetylation at K27 is responsible for its suppression of colon cancer progression. Cancer Letters, 426, 63-72.

Wan, J., Liu, H., Feng, Q., Liu, J., & Ming, L. (2018). HOXB9 promotes endometrial cancer progression by targeting E2F3. Cell death & disease, 9(5), 509.

Lin, J., Zhang, D., Fan, Y., Chao, Y., Chang, J., Li, N., ... & Han, C. (2018). Regulation of cancer stem cell self-renewal by HOXB9 antagonizes endoplasmic reticulum stress-induced melanoma cell apoptosis via the miR-765–FOXA2 axis. Journal of Investigative Dermatology, 138(7), 1609-1619.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-HOXB9 Recombinant Antibody (3C8)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

HOXB9 Matched Antibody Pair (567) (CAT#: APMAB-567LY)

HOXB9 Matched Antibody Pair (568) (CAT#: APMAB-568LY)

Related Products

Mouse Anti-HOXB9 Antibody (1E6) (CAT#: CBMAB-0502-YC)

Mouse Anti-HOXB9 Recombinant Antibody (4C3) (CAT#: CBMAB-A4052-LY)

Mouse Anti-HOXB9 (AA 65-163) Recombinant Antibody (CBFYH-1785) (CAT#: CBMAB-H2795-FY)

HOXB9 Matched Antibody Pair (568) (CAT#: APMAB-568LY)

Rabbit Anti-HOXB9 Recombinant Antibody (EG1546) (CAT#: CBMAB-EN1845-LY)

Mouse Anti-HOXB9 Recombinant Antibody (CBFYH-1788) (CAT#: CBMAB-H2798-FY)

HOXB9 Matched Antibody Pair (567) (CAT#: APMAB-567LY)

Mouse Anti-HOXB9 (AA 65-163) Recombinant Antibody (CBFYH-1784) (CAT#: CBMAB-H2794-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry