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Mouse Anti-HPD Recombinant Antibody (CBFYH-1882) (CBMAB-H2889-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-1882
Antibody Isotype
IgG2a, κ
Application
ELISA, ELISA(Cap), WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
4-hydroxyphenylpyruvate dioxygenase
Introduction
The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
3242
UniProt ID
P32754
Alternative Names
4-Hydroxyphenylpyruvate Dioxygenase; 4-Hydroxyphenylpyruvic Acid Oxidase; Glyoxalase Domain Containing 3; EC 1.13.11.27; HPPDASE; 4HPPD; PPD; 4-HPPD; GLOD3
Function
Key enzyme in the degradation of tyrosine.
Biological Process
L-phenylalanine catabolic process Source: UniProtKB-UniPathway
Tyrosine catabolic process Source: MGI
Cellular Location
Cytosol; Endoplasmic reticulum membrane; Extracellular exosome; Golgi membrane
Involvement in disease
Tyrosinemia 3 (TYRSN3):
An inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, seizures and mild mental retardation.
Hawkinsinuria (HAWK):
An inborn error of tyrosine metabolism characterized by failure to thrive, persistent metabolic acidosis, fine and sparse hair, and excretion of the unusual cyclic amino acid metabolite, hawkinsin, in the urine.
More Infomation

Dong, J., Dong, J., Yu, X. H., Yan, Y. C., Nan, J. X., Ye, B. Q., ... & Yang, G. F. (2023). Discovery of Subnanomolar Inhibitors of 4-Hydroxyphenylpyruvate Dioxygenase via Structure-Based Rational Design. Journal of Agricultural and Food Chemistry, 71(2), 1170-1177.

Lee, H. S., Choi, J. Y., Kwon, S. J., Park, E. S., Oh, B. M., Kim, J. H., & Lee, P. C. (2022). Melanin biopolymer synthesis using a new melanogenic strain of Flavobacterium kingsejongi and a recombinant strain of Escherichia coli expressing 4-hydroxyphenylpyruvate dioxygenase from F. kingsejongi. Microbial Cell Factories, 21(1), 75.

Ghosh, S. G., Lee, S., Fabunan, R., Chai, G., Zaki, M. S., Abdel-Salam, G., ... & Gleeson, J. G. (2021). Biallelic variants in HPDL, encoding 4-hydroxyphenylpyruvate dioxygenase-like protein, lead to an infantile neurodegenerative condition. Genetics in Medicine, 23(3), 524-533.

Neuckermans, J., Lequeue, S., Mertens, A., Branson, S., Schwaneberg, U., & De Kock, J. (2021). High-throughput quantification of ochronotic pigment formation in Escherichia coli to evaluate the potency of human 4-hydroxyphenylpyruvate dioxygenase inhibitors in multi-well format. MethodsX, 8, 101181.

Ye, X., Wei, X., Liao, J., Chen, P., Li, X., Chen, Y., ... & Fang, H. (2021). 4-Hydroxyphenylpyruvate dioxygenase-like protein promotes pancreatic cancer cell progression and is associated with glutamine-mediated redox balance. Frontiers in Oncology, 10, 617190.

Ndikuryayo, F., Kang, W. M., Wu, F. X., Yang, W. C., & Yang, G. F. (2019). Hydrophobicity-oriented drug design (HODD) of new human 4-hydroxyphenylpyruvate dioxygenase inhibitors. European Journal of Medicinal Chemistry, 166, 22-31.

Shan, C., Lu, Z., Li, Z., Sheng, H., Fan, J., Qi, Q., ... & Zhang, S. (2019). 4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis. Cell death & disease, 10(7), 525.

Neuckermans, J., Mertens, A., De Win, D., Schwaneberg, U., & De Kock, J. (2019). A robust bacterial assay for high-throughput screening of human 4-hydroxyphenylpyruvate dioxygenase inhibitors. Scientific reports, 9(1), 14145.

Bolognese, F., Scanferla, C., Caruso, E., & Orlandi, V. T. (2019). Bacterial melanin production by heterologous expression of 4‑hydroxyphenylpyruvate dioxygenase from Pseudomonas aeruginosa. International journal of biological macromolecules, 133, 1072-1080.

Neuckermans, J. (2018). Development of a high-throughput bacterial inhibition assay for human 4-hydroxyphenylpyruvate dioxygenase in the context of tyrosinemia type 1.

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For research use only. Not intended for any clinical use.

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