HPD

The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Full Name

4-hydroxyphenylpyruvate dioxygenase

Function

Key enzyme in the degradation of tyrosine.

Biological Process

L-phenylalanine catabolic process Source: UniProtKB-UniPathway
Tyrosine catabolic process Source: MGI

Cellular Location

Cytosol; Endoplasmic reticulum membrane; Extracellular exosome; Golgi membrane

Involvement in disease

Tyrosinemia 3 (TYRSN3):
An inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, seizures and mild mental retardation.
Hawkinsinuria (HAWK):
An inborn error of tyrosine metabolism characterized by failure to thrive, persistent metabolic acidosis, fine and sparse hair, and excretion of the unusual cyclic amino acid metabolite, hawkinsin, in the urine.

Anti-HPD antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-HPD Recombinant Antibody (CBFYH-1882) (CBMAB-H2889-FY)

Datasheet

SDS

Target: HPD

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYH-1882

Application*: E, EC, WB

Mouse Anti-HPD Recombinant Antibody (CBFYH-1881) (CBMAB-H2888-FY)

Datasheet

SDS

Target: HPD

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYH-1881

Application*: WB, E

Mouse Anti-HPD (AA 160-270) Recombinant Antibody (CBFYH-1879) (CBMAB-H2886-FY)

Datasheet

SDS

Target: HPD

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYH-1879

Application*: WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)