Mouse Anti-JUN Recombinant Antibody (CBT161) (V2LY-0625-LY3751)

Jun proto-oncogene, AP-1 transcription factor subunit

Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3' (PubMed:10995748, PubMed:22083952).

Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646).

Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306).

Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).

Aging Source: Ensembl
Angiogenesis Source: Ensembl
Cellular response to cadmium ion Source: CAFA
Cellular response to potassium ion starvation Source: Ensembl
Cellular response to reactive oxygen species Source: CAFA
Circadian rhythm Source: Ensembl
Fc-epsilon receptor signaling pathway Source: Reactome
Learning Source: Ensembl
Membrane depolarization Source: Ensembl
Negative regulation by host of viral transcription Source: UniProtKB
Negative regulation of DNA binding Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Source: ParkinsonsUK-UCL
Positive regulation by host of viral transcription Source: UniProtKB
Positive regulation of apoptotic process Source: CAFA
Positive regulation of DNA replication Source: Ensembl
Positive regulation of DNA-templated transcription, initiation Source: CACAO
Positive regulation of monocyte differentiation Source: Ensembl
Positive regulation of neuron apoptotic process Source: Ensembl
Positive regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of vascular associated smooth muscle cell proliferation Source: BHF-UCL
Ras protein signal transduction Source: UniProtKB
Regulation of cell cycle Source: GO_Central
Regulation of cell population proliferation Source: GO_Central
Regulation of DNA-binding transcription factor activity Source: Reactome
Regulation of transcription by RNA polymerase II Source: GO_Central
Release of cytochrome c from mitochondria Source: Ensembl
Response to cAMP Source: Ensembl
Response to cytokine Source: Ensembl
Response to drug Source: Ensembl
Response to hydrogen peroxide Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to radiation Source: Ensembl
SMAD protein signal transduction Source: BHF-UCL
Transcription by RNA polymerase II Source: Ensembl
Transforming growth factor beta receptor signaling pathway Source: BHF-UCL

Nucleus

Ubiquitinated by the SCF(FBXW7), leading to its degradation (PubMed:14739463, PubMed:27458189). Ubiquitination takes place following phosphorylation, that promotes interaction with FBXW7 (PubMed:14739463).
Phosphorylated by CaMK4 and PRKDC; phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3. Phosphorylated by DYRK2 at Ser-243; this primes the protein for subsequent phosphorylation by GSK3B at Thr-239. Phosphorylated at Thr-239, Ser-243 and Ser-249 by GSK3B; phosphorylation reduces its ability to bind DNA. Phosphorylated by PAK2 at Thr-2, Thr-8, Thr-89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell proliferation and transformation. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase DNA-binding activity.
Acetylated at Lys-271 by EP300.