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Mouse Anti-KIR2DL4 Recombinant Antibody (CBT4611) (V2LY-0625-LY1166)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4611
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human CD158D (AA: extra 22-120) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 4
Entrez Gene ID
3805
UniProt ID
Q99706
Function
Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:23184984, PubMed:29262349, PubMed:16366734).
May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells (PubMed:10190900, PubMed:16366734).
Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent proinflammatory response (PubMed:20179272).
Biological Process
Cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cellular senescenceManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of natural killer cell cytokine productionManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane; Early endosome membrane
Topology
Extracellular: 22-242
Helical: 243-263
Cytoplasmic: 264-377
More Infomation

Kilic, N., Dastouri, M., Kandemir, I., & Yilmaz, E. (2023). The effects of KIR2DL4 stimulated NK-92 cells on the apoptotic pathways of HER2+/HER-breast cancer cells. Medical Oncology, 40(5), 139.

Feng, Z., Huang, P., Zhang, J., Xia, X., Zhang, A. M., Zeng, T., ... & Yue, M. (2023). KIR2DL4/HLA‐G polymorphisms were associated with HCV infection susceptibility among Chinese high‐risk population. Journal of Medical Virology, 95(3), e28645.

Mao, R., Ren, Z., Yang, F., Yang, P., & Zhang, T. (2022). Clinical significance and immune landscape of KIR2DL4 and the senescence‐based signature in cutaneous melanoma. Cancer Science, 113(11), 3947.

Zheng, G., Jia, L., & Yang, A. G. (2022). Roles of HLA-G/KIR2DL4 in breast cancer immune microenvironment. Frontiers in Immunology, 13, 791975.

Ding, X. F., Chen, J., Ma, H. L., Liang, Y., Wang, Y. F., Zhang, H. T., ... & Chen, G. (2022). KIR2DL4 promotes the proliferation of RCC cell associated with PI3K/Akt signaling activation. Life Sciences, 293, 120320.

Zheng, G., Guo, Z., Li, W., Xi, W., Zuo, B., Zhang, R., ... & Jia, L. (2021). Interaction between HLA-G and NK cell receptor KIR2DL4 orchestrates HER2-positive breast cancer resistance to trastuzumab. Signal Transduction and Targeted Therapy, 6(1), 236.

Bai, Y., Liang, J., Liu, W., Wang, F., & Li, C. (2020). Possible roles of HLA-G regulating immune cells in pregnancy and endometrial diseases via KIR2DL4. Journal of Reproductive Immunology, 142, 103176.

Bespalova, O., Bakleicheva, M., Ivashchenko, T., Tral, T., Tolibova, G., & Kogan, I. (2020). Expression of HLA-G and KIR2DL4 receptor in chorionic villous in missed abortion. Gynecological Endocrinology, 36(sup1), 43-47.

Banerjee, P. P., Pang, L., Soldan, S. S., Miah, S. M., Eisenberg, A., Maru, S., ... & Orange, J. S. (2019). KIR2DL4-HLAG interaction at human NK cell-oligodendrocyte interfaces regulates IFN-γ-mediated effects. Molecular immunology, 115, 39-55.

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For research use only. Not intended for any clinical use.

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