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Mouse Anti-KIR2DL4 Recombinant Antibody (181703) (CBMAB-K0100-LY)

This product is antibody recognizes KIR2DL4. The antibody 181703 immunoassay techniques such as: FC.
See all KIR2DL4 antibodies
Published Data

Summary

Host Animal
Mouse
Specificity
Human
Clone
181703
Antibody Isotype
IgG2a
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 4
Introduction
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternate alleles of this gene are represented on multiple alternate reference loci (ALT_REF_LOCs). Alternative splicing results in multiple transcript variants, some of which may not be annotated on the primary reference assembly. [provided by RefSeq, Jul 2016]
Entrez Gene ID
UniProt ID
Alternative Names
Killer Cell Immunoglobulin Like Receptor; Two Ig Domains And Long Cytoplasmic Tail 4; Killer Cell Immunoglobulin-Like Receptor; Two Domains; Long Cytoplasmic Tail; 4; Killer Cell Inhibitory Receptor 103AS; MHC Class I NK Cell Receptor KIR103AS; CD158 Antigen-Like Family Member D; KIR-103AS; KIR103AS;
Function
Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:23184984, PubMed:29262349, PubMed:16366734).
May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells (PubMed:10190900, PubMed:16366734).
Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent proinflammatory response (PubMed:20179272).
Biological Process
Cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cellular senescenceManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of natural killer cell cytokine productionManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane; Early endosome membrane
Topology
Extracellular: 22-242
Helical: 243-263
Cytoplasmic: 264-377

Kilic, N., Dastouri, M., Kandemir, I., & Yilmaz, E. (2023). The effects of KIR2DL4 stimulated NK-92 cells on the apoptotic pathways of HER2+/HER-breast cancer cells. Medical Oncology, 40(5), 139.

Feng, Z., Huang, P., Zhang, J., Xia, X., Zhang, A. M., Zeng, T., ... & Yue, M. (2023). KIR2DL4/HLA‐G polymorphisms were associated with HCV infection susceptibility among Chinese high‐risk population. Journal of Medical Virology, 95(3), e28645.

Mao, R., Ren, Z., Yang, F., Yang, P., & Zhang, T. (2022). Clinical significance and immune landscape of KIR2DL4 and the senescence‐based signature in cutaneous melanoma. Cancer Science, 113(11), 3947.

Zheng, G., Jia, L., & Yang, A. G. (2022). Roles of HLA-G/KIR2DL4 in breast cancer immune microenvironment. Frontiers in Immunology, 13, 791975.

Ding, X. F., Chen, J., Ma, H. L., Liang, Y., Wang, Y. F., Zhang, H. T., ... & Chen, G. (2022). KIR2DL4 promotes the proliferation of RCC cell associated with PI3K/Akt signaling activation. Life Sciences, 293, 120320.

Zheng, G., Guo, Z., Li, W., Xi, W., Zuo, B., Zhang, R., ... & Jia, L. (2021). Interaction between HLA-G and NK cell receptor KIR2DL4 orchestrates HER2-positive breast cancer resistance to trastuzumab. Signal Transduction and Targeted Therapy, 6(1), 236.

Bai, Y., Liang, J., Liu, W., Wang, F., & Li, C. (2020). Possible roles of HLA-G regulating immune cells in pregnancy and endometrial diseases via KIR2DL4. Journal of Reproductive Immunology, 142, 103176.

Bespalova, O., Bakleicheva, M., Ivashchenko, T., Tral, T., Tolibova, G., & Kogan, I. (2020). Expression of HLA-G and KIR2DL4 receptor in chorionic villous in missed abortion. Gynecological Endocrinology, 36(sup1), 43-47.

Banerjee, P. P., Pang, L., Soldan, S. S., Miah, S. M., Eisenberg, A., Maru, S., ... & Orange, J. S. (2019). KIR2DL4-HLAG interaction at human NK cell-oligodendrocyte interfaces regulates IFN-γ-mediated effects. Molecular immunology, 115, 39-55.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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