Mouse Anti-KLHL21 Recombinant Antibody (CBT816) (V2LY-0625-LY3247)

Name: Mouse Anti-KLHL21 Recombinant Antibody (CBT816)
SKU: V2LY-0625-LY3247
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-KLHL21 Recombinant Antibody (CBT816) (V2LY-0625-LY3247) in IHC

Mouse Anti-KLHL21 Recombinant Antibody (CBT816) (V2LY-0625-LY3247) in WB

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT816

Application

WB, IHC-P, IF, ELISA

Immunogen

Purified recombinant fragment of human KLHL21 expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

Application	Note
ELISA	1:10,000
IHC	1:200-1:1,000
WB	1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Buffer

BSA, Glycerol

Preservative

Sodium azide

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Kelch Like Family Member 21

Entrez Gene ID

9903

UniProt ID

Q9UJP4

Function

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.

Biological Process

Cell cycleIEA:UniProtKB-KW
Cell divisionIEA:UniProtKB-KW
Chromosome passenger complex localization to spindle midzoneManual Assertion Based On ExperimentIMP:UniProtKB
Protein ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm, cytoskeleton, spindle. Localizes to the spindle midzone and targets CUL3 to this region.

Yuan, H., Wei, S., Ren, Z., Li, F., Liu, B., Liu, R., & Zhang, X. (2023). KLHL21/CYLD signaling confers aggressiveness in bladder cancer through inactivating NF-κB signaling. International Immunopharmacology, 114, 109202.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-KLHL21 Recombinant Antibody (13B457) (CAT#: CBMAB-K1191-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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