KLHL21

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.
Full Name
Kelch Like Family Member 21
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.
Biological Process
Cell cycleIEA:UniProtKB-KW
Cell divisionIEA:UniProtKB-KW
Chromosome passenger complex localization to spindle midzoneManual Assertion Based On ExperimentIMP:UniProtKB
Protein ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm, cytoskeleton, spindle. Localizes to the spindle midzone and targets CUL3 to this region.
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Anti-KLHL21 antibodies

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Mouse Anti-KLHL21 Recombinant Antibody (2H4) (CBMAB-K1192-LY)

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Target: KLHL21
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2H4
Application*: E, WB, P, IF/IC, F
Datasheet SDS

Mouse Anti-KLHL21 Recombinant Antibody (13B457) (CBMAB-K1191-LY)

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Target: KLHL21
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B457
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-KLHL21 Recombinant Antibody (CBT816) (V2LY-0625-LY3247)

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Target: KLHL21
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT816
Application*: WB, P, IF, E
Datasheet SDS

Mouse Anti-KLHL21 Recombinant Antibody (CBT4739) (V2LY-0625-LY2470)

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Target: KLHL21
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4739
Application*: IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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