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Mouse Anti-LCAT Recombinant Antibody (A874) (CBMAB-AP4239LY)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
A874
Application
ICC, IHC, IP, WB
Immunogen
Ile290~Ser433
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
LCAT
Entrez Gene ID
3931
UniProt ID
P04180
Alternative Names
phosphatidylcholine-sterol O-acyltransferase, Phospholipid-cholesterol acyltransferase
Function
MAJ516Hu21
Biological Process
Cholesterol esterificationManual Assertion Based On ExperimentIDA:UniProtKB
Cholesterol homeostasisManual Assertion Based On ExperimentIDA:BHF-UCL
Cholesterol metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cholesterol transportManual Assertion Based On ExperimentIDA:MGI
High-density lipoprotein particle remodelingManual Assertion Based On ExperimentIDA:UniProtKB
Lipid metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Lipoprotein biosynthetic processIEA:Ensembl
Phosphatidylcholine biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Phosphatidylcholine metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Phospholipid metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of high-density lipoprotein particle assemblyIEA:Ensembl
Response to copper ionIEA:Ensembl
Response to glucocorticoidIEA:Ensembl
Reverse cholesterol transportManual Assertion Based On ExperimentIDA:BHF-UCL
Very-low-density lipoprotein particle remodelingManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Secreted
Secreted into blood plasma (PubMed:3458198, PubMed:8820107, PubMed:10222237).
Produced in astrocytes and secreted into cerebral spinal fluid (CSF) (PubMed:10222237).
Involvement in disease
Lecithin-cholesterol acyltransferase deficiency (LCATD):
A disorder of lipoprotein metabolism characterized by inadequate esterification of plasmatic cholesterol. Two clinical forms are recognized: complete LCAT deficiency and fish-eye disease. LCATD is generally referred to the complete form which is associated with absence of both alpha and beta LCAT activities resulting in esterification anomalies involving both HDL (alpha-LCAT activity) and LDL (beta-LCAT activity). It causes a typical triad of diffuse corneal opacities, target cell hemolytic anemia, and proteinuria with renal failure.
Fish-eye disease (FED):
A disorder of lipoprotein metabolism due to partial lecithin-cholesterol acyltransferase deficiency that affects only alpha-LCAT activity. FED is characterized by low plasma HDL and corneal opacities due to accumulation of cholesterol deposits in the cornea ('fish-eye').
PTM
O- and N-glycosylated. O-glycosylation on Thr-431 and Ser-433 consists of sialylated galactose beta 1-->3N-acetylgalactosamine structures. N-glycosylated sites contain sialylated triantennary and/or biantennary complex structures.

Gao, H., Wu, J., Sun, Z., Zhang, F., Shi, T., Lu, K., ... & Xue, B. (2022). Influence of lecithin cholesterol acyltransferase alteration during different pathophysiologic conditions: A 45 years bibliometrics analysis. Frontiers in Pharmacology, 13, 1062249.

Vitali, C., Bajaj, A., Nguyen, C., Schnall, J., Chen, J., Stylianou, K., ... & Cuchel, M. (2022). A systematic review of the natural history and biomarkers of primary lecithin: cholesterol acyltransferase deficiency. Journal of lipid research, 63(3).

Sasaki, M., Delawary, M., Sakurai, H., Kobayashi, H., Nakao, N., Tsuru, H., ... & Kubota, K. (2021). Novel LCAT (lecithin: cholesterol acyltransferase) activator DS-8190a prevents the progression of plaque accumulation in atherosclerosis models. Arteriosclerosis, Thrombosis, and Vascular Biology, 41(1), 360-376.

Baragetti, A., Ossoli, A., Strazzella, A., Simonelli, S., Baragetti, I., Grigore, L., ... & Calabresi, L. (2020). Low plasma lecithin: cholesterol acyltransferase (LCAT) concentration predicts chronic kidney disease. Journal of Clinical Medicine, 9(7), 2289.

Norum, K. R., Remaley, A. T., Miettinen, H. E., Strøm, E. H., Balbo, B. E., Sampaio, C. A., ... & Retterstøl, K. (2020). Lecithin: cholesterol acyltransferase: symposium on 50 years of biomedical research from its discovery to latest findings. Journal of Lipid Research, 61(8), 1142-1149.

Ossoli, A., Simonelli, S., Varrenti, M., Morici, N., Oliva, F., Stucchi, M., ... & Calabresi, L. (2019). Recombinant LCAT (lecithin: cholesterol acyltransferase) rescues defective HDL (high-density lipoprotein)-mediated endothelial protection in acute coronary syndrome. Arteriosclerosis, thrombosis, and vascular biology, 39(5), 915-924.

Manthei, K. A., Yang, S. M., Baljinnyam, B., Chang, L., Glukhova, A., Yuan, W., ... & Tesmer, J. J. (2018). Molecular basis for activation of lecithin: cholesterol acyltransferase by a compound that increases HDL cholesterol. Elife, 7, e41604.

Yokoyama, K., Tani, S., Matsuo, R., & Matsumoto, N. (2018). Association of lecithin-cholesterol acyltransferase activity and low-density lipoprotein heterogeneity with atherosclerotic cardiovascular disease risk: a longitudinal pilot study. BMC Cardiovascular Disorders, 18(1), 1-10.

Gebhard, C., Rhainds, D., He, G., Rodés-Cabau, J., Lavi, S., Spence, J. D., ... & Tardif, J. C. (2018). Elevated level of lecithin: cholesterol acyltransferase (LCAT) is associated with reduced coronary atheroma burden. Atherosclerosis, 276, 131-139.

Oldoni, F., Baldassarre, D., Castelnuovo, S., Ossoli, A., Amato, M., van Capelleveen, J., ... & Calabresi, L. (2018). Complete and partial lecithin: cholesterol acyltransferase deficiency is differentially associated with atherosclerosis. Circulation, 138(10), 1000-1007.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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