Mouse Anti-LGALS3 Recombinant Antibody (8D7) (CBMAB-1596-CN)

galectin 3

LGALS3 is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. LGALS3 localizes to the extracellular matrix, the cytoplasm and the nucleus. LGALS3 plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation and exhibits antimicrobial activity against bacteria and fungi.

L31; GAL3; MAC2; CBP35; GALBP; GALIG; LGALS2

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity).
In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes.

Antimicrobial humoral immune response mediated by antimicrobial peptideIDA:UniProtKB
Eosinophil chemotaxisManual Assertion Based On ExperimentIDA:BHF-UCL
Epithelial cell differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Innate immune responseIEA:UniProtKB-KW
Killing of cells of other organismIDA:UniProtKB
Macrophage chemotaxisManual Assertion Based On ExperimentIDA:BHF-UCL
Monocyte chemotaxisManual Assertion Based On ExperimentIDA:BHF-UCL
Mononuclear cell migrationManual Assertion Based On ExperimentIDA:BHF-UCL
mRNA processingIEA:UniProtKB-KW
Negative regulation of endocytosisManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of extrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of immunological synapse formationBy SimilarityISS:BHF-UCL
Negative regulation of protein tyrosine phosphatase activity1 PublicationIC:ARUK-UCL
Negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellBy SimilarityISS:BHF-UCL
Negative regulation of T cell receptor signaling pathwayBy SimilarityISS:BHF-UCL
Neutrophil chemotaxisManual Assertion Based On ExperimentIDA:BHF-UCL
Positive chemotaxisManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of calcium ion importManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of mononuclear cell migrationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of protein-containing complex assemblyManual Assertion Based On ExperimentIDA:ARUK-UCL
Regulation of extrinsic apoptotic signaling pathway via death domain receptorsManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of T cell apoptotic processManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of T cell proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
RNA splicingIEA:UniProtKB-KW

Cytoplasm
Nucleus
Secreted
Secreted by a non-classical secretory pathway and associates with the cell surface. Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059).