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Mouse Anti-MAP2K2 Recombinant Antibody (8D10) (CBMAB-A5190-LY)

The product is antibody recognizes MAP2K2. The antibody 8D10 immunoassay techniques such as: WB, ELISA.
Host Species
Mouse
Application
WB, ELISA
Immunogen
MAP2K2 (AAH00471, 1 a.a. ~ 360 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Antibody Isotype
IgG2b, κ
Specificity
Human
Clone
8D10
Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
Introduction
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq]
Alternative Name
FLJ26075; MAPKK2; MEK2; MKK2; PRKMK2
Entrez Gene ID
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For Research Use Only. Not For Clinical Use.
Cat CBMAB-A5190-LY
Conjugates
Size
Price $
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Second antibody and isotype control