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MAP2K2 Matched Antibody Pair (712) (APMAB-712LY)

This antibody pair set can be used for detecting and quantifying protein level of human MAP2K2.
See all MAP2K2 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-MAP2K2 polyclonal antibody, 100 ug
Detection Antibody
Anti-MAP2K2 Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]
Alternative Names
Mitogen-Activated Protein Kinase Kinase 2; ERK Activator Kinase 2; MAP Kinase Kinase 2; MAPK/ERK Kinase 2; EC 2.7.12.2; PRKMK2; MEK2; MKK2;
Entrez Gene ID
5605
UniProt ID
P36507

Sarkar, A., Chamucero-Millares, J. A., & Rojas, M. (2022). Romulus and Remus of Inflammation: The Conflicting Roles of MAP2K1 and MAP2K2 in Acute Respiratory Distress Syndrome. American Journal of Respiratory Cell and Molecular Biology, 66(5), 479-480.

Hua, Z., Wei, R., Guo, M., Lin, Z., Yu, X., Li, X., ... & Yang, Y. (2022). YTHDF2 promotes multiple myeloma cell proliferation via STAT5A/MAP2K2/p-ERK axis. Oncogene, 41(10), 1482-1491.

Gong, K. Q., Mikacenic, C., Long, M. E., Frevert, C. W., Birkland, T. P., Charron, J., ... & Manicone, A. M. (2022). MAP2K2 delays recovery in murine models of acute lung injury and associates with acute respiratory distress syndrome outcome. American Journal of Respiratory Cell and Molecular Biology, 66(5), 555-563.

Ren, L. X., Qi, J. C., Zhao, A. N., Shi, B., Zhang, H., Wang, D. D., & Yang, Z. (2021). Myc-associated zinc-finger protein promotes clear cell renal cell carcinoma progression through transcriptional activation of the MAP2K2-dependent ERK pathway. Cancer cell international, 21(1), 1-13.

Xu, J., Xiong, H., Zhao, Z., Luo, M., Ju, Y., Yang, G., & Mei, Z. (2021). Genistein suppresses allergic contact dermatitis through regulating the MAP2K2/ERK pathway. Food & Function, 12(10), 4556-4569.

Jacinto, J. G., Häfliger, I. M., Gentile, A., & Drögemüller, C. (2021). A heterozygous missense variant in MAP2K2 in a stillborn romagnola calf with skeletal-cardio-enteric dysplasia. Animals, 11(7), 1931.

Richmond, C. S., Vallatharasu, Y., Deviley, J. A., Vos, C. R., Parsons, B. M., & Kenny, P. A. (2019). Sequential treatment failures in response to BRAF/MEK and immune checkpoint inhibitors mediated by MAP2K2 and B2M mutations in melanoma. Experimental and Molecular Pathology, 110, 104260.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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