Recombinant Mouse Anti-Myeloperoxidase (MPO) Antibody (CB3147) (CBMAB-MD652-LY)

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Basic Information

Host Animal
Mouse
Clone
CB3147
Application
ELISA, FC, IHC(f), IHC(p), WB
Immunogen
Human Myeloperoxidase
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.09% Sodium Azide
Purity
> 95% Purity determined by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Myeloperoxidase
Entrez Gene ID
UniProt ID
Function
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity (PubMed:9922160).

Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage (PubMed:25698971).
Biological Process
Aging Source: Ensembl
Defense response Source: ProtInc
Defense response to bacterium Source: GO_Central
Defense response to fungus Source: Ensembl
Hydrogen peroxide catabolic process Source: BHF-UCL
Hypochlorous acid biosynthetic process Source: Ensembl
Low-density lipoprotein particle remodeling Source: BHF-UCL
Negative regulation of apoptotic process Source: ProtInc
Removal of superoxide radicals Source: Ensembl
Respiratory burst involved in defense response Source: Ensembl
Response to food Source: Ensembl
Response to gold nanoparticle Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to oxidative stress Source: UniProtKB
Response to yeast Source: Ensembl
Cellular Location
Lysosome
Involvement in disease
Myeloperoxidase deficiency (MPOD):
A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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