MPO
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
Full Name
Myeloperoxidase
Function
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity (PubMed:9922160).
Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage (PubMed:25698971).
Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage (PubMed:25698971).
Biological Process
Aging Source: Ensembl
Defense response Source: ProtInc
Defense response to bacterium Source: GO_Central
Defense response to fungus Source: Ensembl
Hydrogen peroxide catabolic process Source: BHF-UCL
Hypochlorous acid biosynthetic process Source: Ensembl
Low-density lipoprotein particle remodeling Source: BHF-UCL
Negative regulation of apoptotic process Source: ProtInc
Removal of superoxide radicals Source: Ensembl
Respiratory burst involved in defense response Source: Ensembl
Response to food Source: Ensembl
Response to gold nanoparticle Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to oxidative stress Source: UniProtKB
Response to yeast Source: Ensembl
Defense response Source: ProtInc
Defense response to bacterium Source: GO_Central
Defense response to fungus Source: Ensembl
Hydrogen peroxide catabolic process Source: BHF-UCL
Hypochlorous acid biosynthetic process Source: Ensembl
Low-density lipoprotein particle remodeling Source: BHF-UCL
Negative regulation of apoptotic process Source: ProtInc
Removal of superoxide radicals Source: Ensembl
Respiratory burst involved in defense response Source: Ensembl
Response to food Source: Ensembl
Response to gold nanoparticle Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to oxidative stress Source: UniProtKB
Response to yeast Source: Ensembl
Cellular Location
Lysosome
Involvement in disease
Myeloperoxidase deficiency (MPOD):
A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis.
A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis.
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Anti-MPO antibodies
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CompareTarget: MPO
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 2G11
Application*: E, IH
Target: MPO
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT896
Application*: WB, E
Target: MPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2842
Application*: WB
Target: MPO
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A1175
Application*: ICC, IHC, IP, WB
Target: MPO
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A1174
Application*: IF, IP, WB
Target: MPO
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A1173
Application*: Dot blot, ELISA
Target: MPO
Host: Mouse
Antibody Isotype: IgG
Specificity: Cattle
Clone: A1172
Application*: ICC, IHC, IP, WB
Target: MPO
Host: Mouse
Antibody Isotype: IgA
Specificity: Human
Clone: A1171
Application*: ELISA, IHC, WB
Target: MPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A1170
Application*: FC
Target: MPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYR0613
Target: MPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYR0612
Application*: E
Target: MPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYR0611
Target: MPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYR0610
Target: MPO
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CB322A
Application*: ELISA
Target: MPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9B12G7,4D8B12,9B12D9,9C11A5
Application*: WB
Target: MPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Mouse
Clone: CBHb392
Application*: FC, Immuno assays
Target: MPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat
Clone: CBHb037
Application*: FC, IHC-F, Immuno assays, IF
Target: MPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBHb308
Application*: FC, IHC-F, Immuno assays, WB
Target: MPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb229
Application*: Immuno assays, WB
Target: MPO
Host: Mouse
Specificity: Human
Clone: IHC629
Application*: IH
Target: MPO
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: 3E11
Application*: WB, E
Target: MPO
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7F5A2
Application*: E
Target: MPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBFYA-0271
Application*: F, C, IA, WB
Target: MPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat
Clone: CBFYA-0213
Application*: F, IA
Target: MPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat
Clone: CBFYA-0022
Application*: F, C, IA, IF
Target: MPO
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-2503
Application*: E, WB
Target: MPO
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-2502
Application*: WB, IC, P, C, E, IP, IF, F
Target: MPO
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-2500
Application*: P
Target: MPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2498
Application*: WB
Target: MPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0710
Application*: E, WB
Target: MPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0466
Application*: E, C, P, IP, WB
Target: MPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBFYM-0464
Application*: E, F, IF, C, WB
Target: MPO
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-0462
Application*: E
Target: MPO
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0176
Application*: F
Target: MPO
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-0161
Application*: E, WB
Target: MPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0138
Application*: E, F, IH, WB
Target: MPO
Host: Mouse
Specificity: Mouse, Rat
Clone: CBFYM-0111
Application*: E, F, IF, IH
Target: MPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0110
Application*: E, F, C, P, WB
Target: MPO
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-0108
Application*: E, SE
Target: MPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0099
Application*: IA, WB
Target: MPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0098
Application*: IF, F
Target: MPO
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 03D03
Application*: E, F
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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