Human MPO ELISA Kit (V2LY-0626-LY1222)

Name: Human MPO ELISA Kit
SKU: V2LY-0626-LY1222
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.05 ng/mL

Detection Range

0.1-30 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

83.9 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Myeloperoxidase

Function

Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity (PubMed:9922160).

Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage (PubMed:25698971).

Biological Process

Aging Source: Ensembl
Defense response Source: ProtInc
Defense response to bacterium Source: GO_Central
Defense response to fungus Source: Ensembl
Hydrogen peroxide catabolic process Source: BHF-UCL
Hypochlorous acid biosynthetic process Source: Ensembl
Low-density lipoprotein particle remodeling Source: BHF-UCL
Negative regulation of apoptotic process Source: ProtInc
Removal of superoxide radicals Source: Ensembl
Respiratory burst involved in defense response Source: Ensembl
Response to food Source: Ensembl
Response to gold nanoparticle Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to oxidative stress Source: UniProtKB
Response to yeast Source: Ensembl

Cellular Location

Lysosome

Involvement in disease

Myeloperoxidase deficiency (MPOD):
A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis.

Frangie, C., & Daher, J. (2022). Role of myeloperoxidase in inflammation and atherosclerosis. Biomedical reports, 16(6), 1-11.

Kargapolova, Y., Geißen, S., Zheng, R., Baldus, S., Winkels, H., & Adam, M. (2021). The enzymatic and non-enzymatic function of myeloperoxidase (MPO) in inflammatory communication. Antioxidants, 10(4), 562.

Chen, S., Chen, H., Du, Q., & Shen, J. (2020). Targeting myeloperoxidase (MPO) mediated oxidative stress and inflammation for reducing brain ischemia injury: Potential application of natural compounds. Frontiers in physiology, 11, 433.

Arnhold, J. (2020). The dual role of myeloperoxidase in immune response. International Journal of Molecular Sciences, 21(21), 8057.

Davies, M. J., & Hawkins, C. L. (2020). The role of myeloperoxidase in biomolecule modification, chronic inflammation, and disease. Antioxidants & Redox Signaling, 32(13), 957-981.

Ramachandra, C. J., Ja, K. M. M., Chua, J., Cong, S., Shim, W., & Hausenloy, D. J. (2020). Myeloperoxidase as a multifaceted target for cardiovascular protection. Antioxidants & redox signaling, 32(15), 1135-1149.

Chaikijurajai, T., & Tang, W. W. (2020). Myeloperoxidase: a potential therapeutic target for coronary artery disease. Expert opinion on therapeutic targets, 24(7), 695-705.

Cheng, D., Talib, J., Stanley, C. P., Rashid, I., Michaëlsson, E., Lindstedt, E. L., ... & Stocker, R. (2019). Inhibition of MPO (myeloperoxidase) attenuates endothelial dysfunction in mouse models of vascular inflammation and atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology, 39(7), 1448-1457.

Ndrepepa, G. (2019). Myeloperoxidase–A bridge linking inflammation and oxidative stress with cardiovascular disease. Clinica chimica acta, 493, 36-51.

Galijasevic, S. (2019). The development of myeloperoxidase inhibitors. Bioorganic & Medicinal Chemistry Letters, 29(1), 1-7.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Mpo ELISA Kit (CAT#: V2LY-0626-LY877)

Human Recombinant MPO protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY5671)

Human Recombinant MPO protein, His Tag (CAT#: V2LY-0526-LY5672)

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Rabbit Anti-MPO Recombinant Antibody (
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Mouse Anti-MPO Recombinant Antibody (A1170) (CAT#: CBMAB-AP4960LY)

Recombinant Mouse Anti-MPO Antibody (CBHb037) (CAT#: CBMAB-Hb787-LY)

Mouse Anti-MPO Recombinant Antibody (CBFYM-0108) (CAT#: CBMAB-M0121-FY)

Mouse Anti-MPO Recombinant Antibody (A1173) (CAT#: CBMAB-AP4867LY)

Mouse Anti-MPO Recombinant Antibody (A1174) (CAT#: CBMAB-AP12276LY)

Human Recombinant MPO protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY5671)

Mouse Anti-MPO Monoclonal Antibody (CBFYR0612) (CAT#: CBMAB-R0612-FY)

Mouse Anti-MPO Recombinant Antibody (CBFYM-0161) (CAT#: CBMAB-M0183-FY)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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