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Mouse Anti-MPO Recombinant Antibody (A1174) (CBMAB-AP12276LY)

The product is antibody recognizes MPO. The antibody A1174 immunoassay techniques such as: IF, IP, WB.
See all MPO antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
A1174
Antibody Isotype
IgG
Application
IF, IP, WB

Basic Information

Immunogen
Recombinant protein of human MPO
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Myeloperoxidase
Introduction
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
Entrez Gene ID
4353
UniProt ID
P05164
Alternative Names
Myeloperoxidase; EC 1.11.1.7; EC 1.11.2.2; EC 1.11.1;
Function
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity (PubMed:9922160).

Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage (PubMed:25698971).
Biological Process
Aging Source: Ensembl
Defense response Source: ProtInc
Defense response to bacterium Source: GO_Central
Defense response to fungus Source: Ensembl
Hydrogen peroxide catabolic process Source: BHF-UCL
Hypochlorous acid biosynthetic process Source: Ensembl
Low-density lipoprotein particle remodeling Source: BHF-UCL
Negative regulation of apoptotic process Source: ProtInc
Removal of superoxide radicals Source: Ensembl
Respiratory burst involved in defense response Source: Ensembl
Response to food Source: Ensembl
Response to gold nanoparticle Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to oxidative stress Source: UniProtKB
Response to yeast Source: Ensembl
Cellular Location
Lysosome
Involvement in disease
Myeloperoxidase deficiency (MPOD):
A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis.

Frangie, C., & Daher, J. (2022). Role of myeloperoxidase in inflammation and atherosclerosis. Biomedical reports, 16(6), 1-11.

Kargapolova, Y., Geißen, S., Zheng, R., Baldus, S., Winkels, H., & Adam, M. (2021). The enzymatic and non-enzymatic function of myeloperoxidase (MPO) in inflammatory communication. Antioxidants, 10(4), 562.

Chen, S., Chen, H., Du, Q., & Shen, J. (2020). Targeting myeloperoxidase (MPO) mediated oxidative stress and inflammation for reducing brain ischemia injury: Potential application of natural compounds. Frontiers in physiology, 11, 433.

Arnhold, J. (2020). The dual role of myeloperoxidase in immune response. International Journal of Molecular Sciences, 21(21), 8057.

Davies, M. J., & Hawkins, C. L. (2020). The role of myeloperoxidase in biomolecule modification, chronic inflammation, and disease. Antioxidants & Redox Signaling, 32(13), 957-981.

Ramachandra, C. J., Ja, K. M. M., Chua, J., Cong, S., Shim, W., & Hausenloy, D. J. (2020). Myeloperoxidase as a multifaceted target for cardiovascular protection. Antioxidants & redox signaling, 32(15), 1135-1149.

Chaikijurajai, T., & Tang, W. W. (2020). Myeloperoxidase: a potential therapeutic target for coronary artery disease. Expert opinion on therapeutic targets, 24(7), 695-705.

Cheng, D., Talib, J., Stanley, C. P., Rashid, I., Michaëlsson, E., Lindstedt, E. L., ... & Stocker, R. (2019). Inhibition of MPO (myeloperoxidase) attenuates endothelial dysfunction in mouse models of vascular inflammation and atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology, 39(7), 1448-1457.

Ndrepepa, G. (2019). Myeloperoxidase–A bridge linking inflammation and oxidative stress with cardiovascular disease. Clinica chimica acta, 493, 36-51.

Galijasevic, S. (2019). The development of myeloperoxidase inhibitors. Bioorganic & Medicinal Chemistry Letters, 29(1), 1-7.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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