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Mouse Anti-MYH2 Recombinant Antibody (A4.74) (CBMAB-0335-CN)


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Summary

Host Animal
Mouse
Specificity
Human, Cattle, C. elegans, Horse, Llama, Pig, Quail, Rodent
Clone
A4.74
Antibody Isotype
IgG1
Application
ELISA, IF, IHC, IP, WB

Basic Information

Immunogen
Partially purified myosin (pyrophosphate extracted) from human adult (22 year old) skeletal muscle
Specificity
Human, Cattle, C. elegans, Horse, Llama, Pig, Quail, Rodent
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MYH2
Introduction
Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. A mutation in this gene results in inclusion body myopathy-3. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Entrez Gene ID
Human4620
Cattle788772
Horse791236
Pig397256
UniProt ID
HumanQ9UKX2
CattleQ9BE41
HorseQ8MJV1
PigQ9TV63
Alternative Names
IBM3; MYH2A; MYPOP; MYHSA2; MYHas8; MyHC-2A; MyHC-Iia
Function
Muscle contraction. Required for cytoskeleton organization (By similarity).
Biological Process
Muscle contraction Source: BHF-UCL
Muscle filament sliding Source: BHF-UCL
Cellular Location
Other locations
myofibril
Note: Thick filaments of the myofibrils.
Involvement in disease
Myopathy, proximal, with ophthalmoplegia (MYPOP):
A muscular disorder characterized by mild-to-moderate muscle weakness, ophthalmoplegia, and contractures at birth in some patients. Muscle biopsies from patients show predominance of type 1 fibers and small or absent type 2A fibers. The disease is non-progressive or it progresses very slowly. Inheritance is autosomal dominant or recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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