Mouse Anti-MYH2 Recombinant Antibody (A4.1519) (CBMAB-0334-CN)

Name: Mouse Anti-MYH2 Recombinant Antibody (A4.1519)
SKU: CBMAB-0334-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A4.1519

Application

ELISA, IF, IHC, IP, WB

Immunogen

Partially purified myosin (pyrophosphate extracted) from adult (22 year old) skeletal muscle

Specificity

Human, Pig, Rodent

Antibody Isotype

IgM

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

>95%, as determined by SDS-PAGE analysis

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

MYH2

Introduction

Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. A mutation in this gene results in inclusion body myopathy-3. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Entrez Gene ID

Human	4620
Pig	397256

UniProt ID

Human	Q9UKX2
Pig	Q9TV63

Alternative Names

IBM3; MYH2A; MYPOP; MYHSA2; MYHas8; MyHC-2A; MyHC-Iia

Function

Muscle contraction. Required for cytoskeleton organization (By similarity).

Biological Process

Muscle contraction Source: BHF-UCL
Muscle filament sliding Source: BHF-UCL

Cellular Location

Other locations
myofibril
Note: Thick filaments of the myofibrils.

Involvement in disease

Myopathy, proximal, with ophthalmoplegia (MYPOP):
A muscular disorder characterized by mild-to-moderate muscle weakness, ophthalmoplegia, and contractures at birth in some patients. Muscle biopsies from patients show predominance of type 1 fibers and small or absent type 2A fibers. The disease is non-progressive or it progresses very slowly. Inheritance is autosomal dominant or recessive.

Jo, S., Lee, S. H., Jeon, C., Jo, H. R., You, Y. J., Lee, J. K., ... & Lee, C. H. (2023). Myosin heavy chain 2 (MYH2) expression in hypertrophic chondrocytes of soft callus provokes endochondral bone formation in fracture. Life Sciences, 334, 122204.

Sonne, A., Peverelli, L., Hernandez-Lain, A., Domínguez-González, C., Andersen, J. L., Milone, M., ... & Ochala, J. (2023). Myosin post-translational modifications and function in the presence of myopathy-linked truncating MYH2 mutations. American Journal of Physiology-Cell Physiology, 324(3), C769-C776.

Hitachi, K., Kiyofuji, Y., Yamaguchi, H., Nakatani, M., Inui, M., & Tsuchida, K. (2023). Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe skeletal muscle hypoplasia in postnatal mice. The FASEB Journal, 37(1), e22692.

Hedberg-Oldfors, C., Elíasdóttir, Ó., Geijer, M., Lindberg, C., & Oldfors, A. (2022). Dominantly inherited myosin IIa myopathy caused by aberrant splicing of MYH2. BMC neurology, 22(1), 1-9.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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