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MYH2

Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction.

Full Name

MYH2

Function

Muscle contraction. Required for cytoskeleton organization (By similarity).

Biological Process

Muscle contraction Source: BHF-UCL
Muscle filament sliding Source: BHF-UCL

Cellular Location

Other locations
myofibril
Note: Thick filaments of the myofibrils.

Involvement in disease

Myopathy, proximal, with ophthalmoplegia (MYPOP):
A muscular disorder characterized by mild-to-moderate muscle weakness, ophthalmoplegia, and contractures at birth in some patients. Muscle biopsies from patients show predominance of type 1 fibers and small or absent type 2A fibers. The disease is non-progressive or it progresses very slowly. Inheritance is autosomal dominant or recessive.

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Anti-MYH2 antibodies

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Mouse Anti-MYH2 Antibody (BF-35) (CBMAB-1438CQ)

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Target: MYH2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cattle, Dog, Horse, Cat, Goat, Guinea pig, Human, Pig, Rodent

Clone: BF-35

Application*: IF, IH, WB

Mouse Anti-MYH2 Antibody (BF-32) (CBMAB-1437CQ)

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Target: MYH2

Host: Mouse

Antibody Isotype: IgM

Specificity: Cattle, Human, Sheep, Rodent

Clone: BF-32

Application*: IF, IH, WB

Mouse Anti-MYH2 Recombinant Antibody (CBFYM-2932) (CBMAB-M3127-FY)

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Target: MYH2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rabbit, Rat

Clone: CBFYM-2932

Application*: IH, WB

Mouse Anti-MYH2 Recombinant Antibody (CBFYM-0438) (CBMAB-M0553-FY)

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Target: MYH2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat, Rabbit

Clone: CBFYM-0438

Application*: E, IH, IF, P

Mouse Anti-MYH2 Recombinant Antibody (A4.74) (CBMAB-0335-CN)

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Target: MYH2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Cattle, C. elegans, Horse, Llama, Pig, Quail, Rodent

Clone: A4.74

Application*: E, IF, IH, IP, WB

Mouse Anti-MYH2 Recombinant Antibody (A4.1519) (CBMAB-0334-CN)

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Target: MYH2

Host: Mouse

Antibody Isotype: IgM

Specificity: Human, Pig, Rodent

Clone: A4.1519

Application*: E, IF, IH, IP, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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