MYH2

Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction.

Full Name

MYH2

Function

Muscle contraction. Required for cytoskeleton organization (By similarity).

Biological Process

Muscle contraction Source: BHF-UCL
Muscle filament sliding Source: BHF-UCL

Cellular Location

Other locations
myofibril
Note: Thick filaments of the myofibrils.

Involvement in disease

Myopathy, proximal, with ophthalmoplegia (MYPOP):
A muscular disorder characterized by mild-to-moderate muscle weakness, ophthalmoplegia, and contractures at birth in some patients. Muscle biopsies from patients show predominance of type 1 fibers and small or absent type 2A fibers. The disease is non-progressive or it progresses very slowly. Inheritance is autosomal dominant or recessive.

Anti-MYH2 antibodies

Mouse Anti-MYH2 Antibody (BF-35) (CBMAB-1438CQ)

Datasheet

SDS

Target: MYH2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cattle, Dog, Horse, Cat, Goat, Guinea pig, Human, Pig, Rodent

Clone: BF-35

Application*: IF, IH, WB

Mouse Anti-MYH2 Antibody (BF-32) (CBMAB-1437CQ)

Datasheet

SDS

Target: MYH2

Host: Mouse

Antibody Isotype: IgM

Specificity: Cattle, Human, Sheep, Rodent

Clone: BF-32

Application*: IF, IH, WB

Mouse Anti-MYH2 Recombinant Antibody (CBFYM-2932) (CBMAB-M3127-FY)

Datasheet

SDS

Target: MYH2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rabbit, Rat

Clone: CBFYM-2932

Application*: IH, WB

Mouse Anti-MYH2 Recombinant Antibody (CBFYM-0438) (CBMAB-M0553-FY)

Datasheet

SDS

Target: MYH2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat, Rabbit

Clone: CBFYM-0438

Application*: E, IH, IF, P

Mouse Anti-MYH2 Recombinant Antibody (A4.74) (CBMAB-0335-CN)

Datasheet

SDS

Target: MYH2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Cattle, C. elegans, Horse, Llama, Pig, Quail, Rodent

Clone: A4.74

Application*: E, IF, IH, IP, WB

Mouse Anti-MYH2 Recombinant Antibody (A4.1519) (CBMAB-0334-CN)

Datasheet

SDS

Target: MYH2

Host: Mouse

Antibody Isotype: IgM

Specificity: Human, Pig, Rodent

Clone: A4.1519

Application*: E, IF, IH, IP, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)