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Mouse Anti-MYH2 Recombinant Antibody (CBFYM-2932) (CBMAB-M3127-FY)

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Basic Information

Host Animal
Mouse
Clone
CBFYM-2932
Application
IHC, WB
Immunogen
Rabbit muscle myosin
Specificity
Human, Mouse, Rabbit, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
MYH2
Introduction
Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in inclusion body myopathy-3. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Entrez Gene ID
Human4620
Mouse17882
Rat691644
Rabbit100009054
UniProt ID
HumanQ9UKX2
MouseI6L963
RatG3V6E1
Alternative Names
Myosin Heavy Chain 2; Myosin, Heavy Polypeptide 2, Skeletal Muscle, Adult; Inclusion Body Myopathy 3, Autosomal Dominant; Myosin Heavy Chain, Skeletal Muscle, Adult 2; Myosin Heavy Chain IIa; Myosin Heavy Chain 2a; MyHC-IIa; MyHC-2A; MYHSA2; Myosin, Heavy Chain 2, Skeletal Muscle, Adult
Function
Muscle contraction. Required for cytoskeleton organization (By similarity).
Biological Process
Muscle contraction Source: BHF-UCL
Muscle filament sliding Source: BHF-UCL
Cellular Location
Other locations
myofibril
Note: Thick filaments of the myofibrils.
Involvement in disease
Myopathy, proximal, with ophthalmoplegia (MYPOP):
A muscular disorder characterized by mild-to-moderate muscle weakness, ophthalmoplegia, and contractures at birth in some patients. Muscle biopsies from patients show predominance of type 1 fibers and small or absent type 2A fibers. The disease is non-progressive or it progresses very slowly. Inheritance is autosomal dominant or recessive.

Jo, S., Lee, S. H., Jeon, C., Jo, H. R., You, Y. J., Lee, J. K., ... & Lee, C. H. (2023). Myosin heavy chain 2 (MYH2) expression in hypertrophic chondrocytes of soft callus provokes endochondral bone formation in fracture. Life Sciences, 334, 122204.

Sonne, A., Peverelli, L., Hernandez-Lain, A., Domínguez-González, C., Andersen, J. L., Milone, M., ... & Ochala, J. (2023). Myosin post-translational modifications and function in the presence of myopathy-linked truncating MYH2 mutations. American Journal of Physiology-Cell Physiology, 324(3), C769-C776.

Hitachi, K., Kiyofuji, Y., Yamaguchi, H., Nakatani, M., Inui, M., & Tsuchida, K. (2023). Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe skeletal muscle hypoplasia in postnatal mice. The FASEB Journal, 37(1), e22692.

Hedberg-Oldfors, C., Elíasdóttir, Ó., Geijer, M., Lindberg, C., & Oldfors, A. (2022). Dominantly inherited myosin IIa myopathy caused by aberrant splicing of MYH2. BMC neurology, 22(1), 1-9.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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