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Mouse Anti-MYH2 Antibody (BF-32) (CBMAB-1437CQ)

This product is a mouse antibody that recognizes MYH2. The antibody BF-32 can be used for immunoassay techniques such as: IF, IHC, WB.
See all MYH2 antibodies

Summary

Host Animal
Mouse
Specificity
Cattle, Human, Sheep, Rodent
Clone
BF-32
Antibody Isotype
IgM
Application
IF, IHC, WB

Basic Information

Immunogen
Purified myosin from bovine skeletal muscle (fetal, 3 months)
Specificity
Cattle, Human, Sheep, Rodent
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MYH2
Introduction
Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. Diseases associated with MYH2 include Proximal Myopathy And Ophthalmoplegia and Inclusion Body Myositis. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Actin Nucleation by ARP-WASP Complex.
Entrez Gene ID
Human4620
Cattle788772
Sheep443471
UniProt ID
HumanQ9UKX2
CattleQ9BE41
SheepW5PT09
Alternative Names
MyHC-2a; myosin; heavy chain 2; skeletal muscle; adult
Function
Muscle contraction. Required for cytoskeleton organization (By similarity).
Biological Process
Muscle contraction Source: BHF-UCL
Muscle filament sliding Source: BHF-UCL
Cellular Location
Other locations
myofibril
Note: Thick filaments of the myofibrils.
Involvement in disease
Myopathy, proximal, with ophthalmoplegia (MYPOP):
A muscular disorder characterized by mild-to-moderate muscle weakness, ophthalmoplegia, and contractures at birth in some patients. Muscle biopsies from patients show predominance of type 1 fibers and small or absent type 2A fibers. The disease is non-progressive or it progresses very slowly. Inheritance is autosomal dominant or recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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