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Mouse Anti-MYH2 Antibody (BF-35) (CBMAB-1438CQ)


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Summary

Host Animal
Mouse
Specificity
Cattle, Dog, Horse, Cat, Goat, Guinea pig, Human, Pig, Rodent
Clone
BF-35
Antibody Isotype
IgG1
Application
IF, IHC, WB

Basic Information

Immunogen
Purified myosin from bovine skeletal muscle (fetal, 3 months)
Specificity
Cattle, Dog, Horse, Cat, Goat, Guinea pig, Human, Pig, Rodent
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction
Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. Diseases associated with MYH2 include Proximal Myopathy And Ophthalmoplegia and Inclusion Body Myositis. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Actin Nucleation by ARP-WASP Complex.
Entrez Gene ID
Human4620
Cattle788772
Goat102181155
Horse791236
Cat101085328
Guinea pig100727012
Pig397256
Dog608242
UniProt ID
HumanQ9UKX2
CattleQ9BE41
GoatA0A452G8R7
HorseQ8MJV1
CatA0A337SF79
Guinea pigH0V2N7
PigQ9TV63
DogQ076A7
Alternative Names
MyHC-2a; myosin; heavy chain 2; skeletal muscle; adult
Function
Muscle contraction. Required for cytoskeleton organization (By similarity).
Biological Process
Muscle contraction Source: BHF-UCL
Muscle filament sliding Source: BHF-UCL
Cellular Location
Other locations
myofibril
Note: Thick filaments of the myofibrils.
Involvement in disease
Myopathy, proximal, with ophthalmoplegia (MYPOP):
A muscular disorder characterized by mild-to-moderate muscle weakness, ophthalmoplegia, and contractures at birth in some patients. Muscle biopsies from patients show predominance of type 1 fibers and small or absent type 2A fibers. The disease is non-progressive or it progresses very slowly. Inheritance is autosomal dominant or recessive.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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