Mouse Anti-MYO18A Recombinant Antibody (CBWJC-4227) (CBMAB-C5579WJ)

Name: Mouse Anti-MYO18A Recombinant Antibody (CBWJC-4227)
SKU: CBMAB-C5579WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJC-4227

Application

Specificity

Human

Antibody Isotype

IgG1, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Preservative

0.09% sodium azide

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Myosin XVIIIA

Introduction

The protein encoded by this gene can bind GOLPH3, linking the Golgi to the cytoskeleton and influencing Golgi membrane trafficking. The encoded protein is also part of a complex that assembles lamellar actomyosin bundles and may be required for cell migration. [provided by RefSeq, Oct 2016]

Entrez Gene ID

399687

UniProt ID

Q92614

Alternative Names

Myosin XVIIIA; Molecule Associated With JAK3 N-Terminus; Surfactant Protein Receptor SP-R210; Myosin Containing A PDZ Domain; SP-R210; MYSPDZ; MAJN; SP-A Receptor Subunit SP-R210 AlphaS;

Function

May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592).

Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160).

May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity).

Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346).

Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169).

Strongly enhances natural killer cell cytotoxicity (PubMed:27467939).

Biological Process

Actomyosin structure organization Source: UniProtKB
Asymmetric Golgi ribbon formation Source: CACAO
Cell migration Source: UniProtKB
DNA metabolic process Source: InterPro
Golgi organization Source: UniProtKB
Golgi ribbon formation Source: CACAO
Golgi vesicle budding Source: UniProtKB
Negative regulation of apoptotic process Source: CACAO
Positive regulation of opsonization Source: UniProtKB
Positive regulation of protein secretion Source: UniProtKB
Regulation of macrophage activation Source: UniProtKB

Cellular Location

Golgi apparatus
trans-Golgi network
Golgi outpost
Cytoskeleton
microtubule organizing center
Note: Recruited to the Golgi apparatus by GOLPH3 (PubMed:19837035). Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation (By similarity).
Isoform 1:
Cytoskeleton
Other locations
Endoplasmic reticulum-Golgi intermediate compartment
Note: Colocalizes with actin.
Isoform 2:
Cytoplasm
Note: Lacks the PDZ domain (PubMed:12761286). Diffusely localized in the cytoplasm (PubMed:12761286).
Isoform 5:
Other locations
Cell surface

Yang, Q., Liu, H., Zhong, D., Li, Z., Li, J., Xiao, K., & Liu, W. (2024). Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes liquid-liquid phase separation. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1871(2), 119650.

Liu, J., Ren, G., Li, K., Liu, Z., Wang, Y., Chen, T., ... & Xu, Y. (2022). The Smad4-MYO18A-PP1A complex regulates β-catenin phosphorylation and pemigatinib resistance by inhibiting PAK1 in cholangiocarcinoma. Cell Death & Differentiation, 29(4), 818-831.

Perez Carrillo, L., Trivino, J. C., Sanchez Lazaro, I., Martinez Dolz, L., Portoles, M., Tarazon, E., & Rosello-Lleti, E. (2021). Sarcomere ACTC1 and MYO18A serum expression levels detect acute cellular rejection in cardiac transplant patients. European Heart Journal, 42(Supplement_1), ehab724-2269.

Yau, E., Chen, Y., Song, C., Webb, J., Carillo, M., Kawasawa, Y. I., ... & Chroneos, Z. C. (2021). Genomic and epigenomic adaptation in SP-R210 (Myo18A) isoform-deficient macrophages. Immunobiology, 226(6), 152150.

Lin, P. C., Yeh, Y. M., Lin, B. W., Lin, S. C., Chan, R. H., Chen, P. C., & Shen, M. R. (2020). Intratumor heterogeneity of MYO18A and FBXW7 variants impact the clinical outcome of stage III colorectal cancer. Frontiers in oncology, 10, 588557.

Horsthemke, M., Nutter, L. M., Bachg, A. C., Skryabin, B. V., Honnert, U., Zobel, T., ... & Hanley, P. J. (2019). A novel isoform of myosin 18A (Myo18Aγ) is an essential sarcomeric protein in mouse heart. Journal of Biological Chemistry, 294(18), 7202-7218.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

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