MYO18A

The protein encoded by this gene can bind GOLPH3, linking the Golgi to the cytoskeleton and influencing Golgi membrane trafficking. The encoded protein is also part of a complex that assembles lamellar actomyosin bundles and may be required for cell migration. [provided by RefSeq, Oct 2016]

Full Name

Myosin XVIIIA

Function

May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592).

Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160).

May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity).

Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346).

Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169).

Strongly enhances natural killer cell cytotoxicity (PubMed:27467939).

Biological Process

Actomyosin structure organization Source: UniProtKB
Asymmetric Golgi ribbon formation Source: CACAO
Cell migration Source: UniProtKB
DNA metabolic process Source: InterPro
Golgi organization Source: UniProtKB
Golgi ribbon formation Source: CACAO
Golgi vesicle budding Source: UniProtKB
Negative regulation of apoptotic process Source: CACAO
Positive regulation of opsonization Source: UniProtKB
Positive regulation of protein secretion Source: UniProtKB
Regulation of macrophage activation Source: UniProtKB

Cellular Location

Golgi apparatus
trans-Golgi network
Golgi outpost
Cytoskeleton
microtubule organizing center
Note: Recruited to the Golgi apparatus by GOLPH3 (PubMed:19837035). Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation (By similarity).
Isoform 1:
Cytoskeleton
Other locations
Endoplasmic reticulum-Golgi intermediate compartment
Note: Colocalizes with actin.
Isoform 2:
Cytoplasm
Note: Lacks the PDZ domain (PubMed:12761286). Diffusely localized in the cytoplasm (PubMed:12761286).
Isoform 5:
Other locations
Cell surface