Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-NR1I2 Recombinant Antibody (CBT2360) (V2LY-0625-LY589)


See all NR1I2 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2360
Antibody Isotype
IgG2b
Application
ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human NR1I2 (AA: 1-142) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ICC1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Nuclear Receptor Subfamily 1 Group I Member 2
Entrez Gene ID
8856
UniProt ID
O75469
Function
Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.
Biological Process
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:MGI
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:GO_Central
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Steroid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Xenobiotic catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Xenobiotic metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Xenobiotic transportManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
More Infomation

Amini, S. E., Bresson, S. E., & Ruzzin, J. N. M. (2023). Mice lacking intestinal Nr1i2 have normal intestinal homeostasis under steady-state conditions and are not hypersensitive to inflammation under lipopolysaccharide treatment. The FASEB Journal, 37(8).

Nilles, J., Weiss, J., Masin, M., Tuffs, C., Strowitzki, M. J., Haefeli, W. E., ... & Theile, D. (2023). The differences in drug disposition gene induction by rifampicin and rifabutin are unlikely due to different effects on important pregnane X receptor (NR1I2) splice variants. Naunyn-Schmiedeberg's Archives of Pharmacology, 1-12.

de Almeida Velozo, C., de Almeida, T. B., de Azevedo, M. C. V. M., Espasandin, I., da Cunha Pinto, J. F., López, S., ... & Cardoso, C. C. (2022). Polymorphisms at CYP enzymes, NR1I2 and NR1I3 in association with virologic response to antiretroviral therapy in Brazilian HIV-positive individuals. The Pharmacogenomics Journal, 22(1), 33-38.

Yagishita, H., Kagaya, H., Saito, M., Numakura, K., Yamamoto, R., Sagehashi, R., ... & Miura, M. (2022). Effects of NR1I2 and ABCB1 Genetic Polymorphisms on Everolimus Pharmacokinetics in Japanese Renal Transplant Patients. International Journal of Molecular Sciences, 23(19), 11742.

Lu, Y., Xu, L., Cui, J., Shen, S., & Li, X. (2021). Effects of Postoperative Day and NR1I2 on Tacrolimus Clearance in Chinese Liver Transplant Recipients—A Population Model Approach. Clinical Pharmacology in Drug Development, 10(11), 1385-1394.

Yang, M., Pan, H., Chen, H., Liu, W., Lu, L., He, X., ... & Tang, S. (2020). Association between NR1I2 polymorphisms and susceptibility to anti-tuberculosis drug-induced hepatotoxicity in an Eastern Chinese Han population: A case-control study. Infection, Genetics and Evolution, 83, 104349.

Yang, M., Qiu, Y., Jin, Y., Liu, W., Wang, Q., Yi, H., & Tang, S. (2020). NR1I2 genetic polymorphisms and the risk of anti‐tuberculosis drug‐induced hepatotoxicity: A systematic review and meta‐analysis. Pharmacology Research & Perspectives, 8(6), e00696.

Elliot, E. R., Neary, M., Else, L., Khoo, S., Moyle, G., Carr, D. F., ... & Owen, A. (2020). Genetic influence of ABCG2, UGT1A1 and NR1I2 on dolutegravir plasma pharmacokinetics. Journal of Antimicrobial Chemotherapy, 75(5), 1259-1266.

Chen, Y. B., Zhou, Z. Y., Li, G. M., Xiao, C. X., Yu, W. B., Zhong, S. L., ... & Huang, M. (2019). Influences of an NR1I2 polymorphism on heterogeneous antiplatelet reactivity responses to clopidogrel and clinical outcomes in acute ischemic stroke patients. Acta Pharmacologica Sinica, 40(6), 762-768.

Lille-Langøy, R., Karlsen, O. A., Myklebust, L. M., Goldstone, J. V., Mork-Jansson, A., Male, R., ... & Goksøyr, A. (2019). Sequence variations in pxr (nr1i2) from zebrafish (Danio rerio) strains affect nuclear receptor function. Toxicological Sciences, 168(1), 28-39.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-NR1I2 Recombinant Antibody (CBT2360)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry