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Recombinant Mouse Anti-NR1I2 Recombinant Antibody (V11P4G11) (CBMAB-XB0884-YC)

Provided herein is a Mouse Recombinant Antibody against Nuclear Receptor Subfamily 1 Group I Member 2. The antibody can be used for immunoassay techniques, such as ELISA, IHC, WB.
See all NR1I2 antibodies
Published Data
Fig.1 The normal human colon mucosae express PXR in the cytoplasm (indicated by arrow).
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Fig.2 PXR gene expression was confirmed by western blot analysis.
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Summary

Host Animal
Mouse
Specificity
Zebrafish
Clone
V11P4G11
Antibody Isotype
IgG1, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Ovalbumin-conjugated Synthetic peptide EMRSMNEEYT (C-terminal sequence)
Specificity
Zebrafish
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Nuclear Receptor Subfamily 1 Group I Member 2
Introduction
NR1I2 product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.
Entrez Gene ID
565875
UniProt ID
B0V1H8
Alternative Names
Nuclear Receptor Subfamily 1 Group I Member 2; Orphan Nuclear Receptor PXR; Pregnane X Receptor; Steroid And Xenobiotic Receptor; Orphan Nuclear Receptor PAR1; PXR; SXR; Nuclear Receptor Subfamily 1, Group I, Member 2; Pregnane X Nuclear Receptor Variant 2;
Function
Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.
Biological Process
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:MGI
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:GO_Central
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Steroid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Xenobiotic catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Xenobiotic metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Xenobiotic transportManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus

Amini, S. E., Bresson, S. E., & Ruzzin, J. N. M. (2023). Mice lacking intestinal Nr1i2 have normal intestinal homeostasis under steady-state conditions and are not hypersensitive to inflammation under lipopolysaccharide treatment. The FASEB Journal, 37(8).

Nilles, J., Weiss, J., Masin, M., Tuffs, C., Strowitzki, M. J., Haefeli, W. E., ... & Theile, D. (2023). The differences in drug disposition gene induction by rifampicin and rifabutin are unlikely due to different effects on important pregnane X receptor (NR1I2) splice variants. Naunyn-Schmiedeberg's Archives of Pharmacology, 1-12.

de Almeida Velozo, C., de Almeida, T. B., de Azevedo, M. C. V. M., Espasandin, I., da Cunha Pinto, J. F., López, S., ... & Cardoso, C. C. (2022). Polymorphisms at CYP enzymes, NR1I2 and NR1I3 in association with virologic response to antiretroviral therapy in Brazilian HIV-positive individuals. The Pharmacogenomics Journal, 22(1), 33-38.

Yagishita, H., Kagaya, H., Saito, M., Numakura, K., Yamamoto, R., Sagehashi, R., ... & Miura, M. (2022). Effects of NR1I2 and ABCB1 Genetic Polymorphisms on Everolimus Pharmacokinetics in Japanese Renal Transplant Patients. International Journal of Molecular Sciences, 23(19), 11742.

Lu, Y., Xu, L., Cui, J., Shen, S., & Li, X. (2021). Effects of Postoperative Day and NR1I2 on Tacrolimus Clearance in Chinese Liver Transplant Recipients—A Population Model Approach. Clinical Pharmacology in Drug Development, 10(11), 1385-1394.

Yang, M., Pan, H., Chen, H., Liu, W., Lu, L., He, X., ... & Tang, S. (2020). Association between NR1I2 polymorphisms and susceptibility to anti-tuberculosis drug-induced hepatotoxicity in an Eastern Chinese Han population: A case-control study. Infection, Genetics and Evolution, 83, 104349.

Yang, M., Qiu, Y., Jin, Y., Liu, W., Wang, Q., Yi, H., & Tang, S. (2020). NR1I2 genetic polymorphisms and the risk of anti‐tuberculosis drug‐induced hepatotoxicity: A systematic review and meta‐analysis. Pharmacology Research & Perspectives, 8(6), e00696.

Elliot, E. R., Neary, M., Else, L., Khoo, S., Moyle, G., Carr, D. F., ... & Owen, A. (2020). Genetic influence of ABCG2, UGT1A1 and NR1I2 on dolutegravir plasma pharmacokinetics. Journal of Antimicrobial Chemotherapy, 75(5), 1259-1266.

Chen, Y. B., Zhou, Z. Y., Li, G. M., Xiao, C. X., Yu, W. B., Zhong, S. L., ... & Huang, M. (2019). Influences of an NR1I2 polymorphism on heterogeneous antiplatelet reactivity responses to clopidogrel and clinical outcomes in acute ischemic stroke patients. Acta Pharmacologica Sinica, 40(6), 762-768.

Lille-Langøy, R., Karlsen, O. A., Myklebust, L. M., Goldstone, J. V., Mork-Jansson, A., Male, R., ... & Goksøyr, A. (2019). Sequence variations in pxr (nr1i2) from zebrafish (Danio rerio) strains affect nuclear receptor function. Toxicological Sciences, 168(1), 28-39.

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For research use only. Not intended for any clinical use.

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