Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-OTUB2 Recombinant Antibody (CBT3143) (V2LY-0625-LY1844)


See all OTUB2 antibodies
Online Inquiry
Tested Data
Mouse Anti-OTUB2 Recombinant Antibody (CBT3143) (V2LY-0625-LY1844) in ELISA
Mouse Anti-OTUB2 Recombinant Antibody (CBT3143) (V2LY-0625-LY1844) in ELISA
Mouse Anti-OTUB2 Recombinant Antibody (CBT3143) (V2LY-0625-LY1844) in WB
Mouse Anti-OTUB2 Recombinant Antibody (CBT3143) (V2LY-0625-LY1844) in WB
Mouse Anti-OTUB2 Recombinant Antibody (CBT3143) (V2LY-0625-LY1844) in WB
Mouse Anti-OTUB2 Recombinant Antibody (CBT3143) (V2LY-0625-LY1844) in WB
Mouse Anti-OTUB2 Recombinant Antibody (CBT3143) (V2LY-0625-LY1844) in FC
Mouse Anti-OTUB2 Recombinant Antibody (CBT3143) (V2LY-0625-LY1844) in FC
Mouse Anti-OTUB2 Recombinant Antibody (CBT3143) (V2LY-0625-LY1844) in FC
Mouse Anti-OTUB2 Recombinant Antibody (CBT3143) (V2LY-0625-LY1844) in FC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3143
Antibody Isotype
IgG1
Application
WB, FC

Basic Information

Immunogen
Purified recombinant fragment of human OTUB2 (AA:full(1-234)) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
OTUB2
Entrez Gene ID
78990
UniProt ID
Q96DC9
Function
Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.
Biological Process
Negative regulation of double-strand break repairManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of histone H2A K63-linked ubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Protein deubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Protein K11-linked deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Protein K48-linked deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Protein K63-linked deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
More Infomation

Ren, W., Xu, Z., Chang, Y., Ju, F., Wu, H., Liang, Z., ... & Xia, N. (2024). Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1. Nature Communications, 15(1), 9.

Xiao, J., Wang, L., Zhuang, Y., Zhu, Q., Li, W., Liao, H., ... & Liu, Z. (2024). The deubiquitinase OTUB2 promotes cervical cancer growth through stabilizing FOXM1. American Journal of Translational Research, 16(1), 75.

Zhang, Q., Zhang, J., Yao, A., Tian, X., Han, Z., Yuan, Y., ... & Yang, X. (2023). OTUB2 promotes the progression of endometrial cancer by regulating the PKM2‐mediated PI3K/AKT signaling pathway. Cell Biology International, 47(2), 428-438.

Ouyang, S., Zeng, Z., Liu, Z., Zhang, Z., Sun, J., Wang, X., ... & Kang, W. (2022). OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer. Cell Death Discovery, 8(1), 45.

Yu, S., Zang, W., Qiu, Y., Liao, L., & Zheng, X. (2022). Deubiquitinase OTUB2 exacerbates the progression of colorectal cancer by promoting PKM2 activity and glycolysis. Oncogene, 41(1), 46-56.

Hu, G., Yang, J., Zhang, H., Huang, Z., & Yang, H. (2022). OTUB2 promotes proliferation and migration of hepatocellular carcinoma cells by PJA1 deubiquitylation. Cellular and Molecular Bioengineering, 15(3), 281-292.

Sivakumar, D., Kumar, V., Naumann, M., & Stein, M. (2020). Activation and selectivity of OTUB-1 and OTUB-2 deubiquitinylases. Journal of Biological Chemistry, 295(20), 6972-6982.

Li, J., Cheng, D., Zhu, M., Yu, H., Pan, Z., Liu, L., ... & Yao, M. (2019). OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer. Theranostics, 9(1), 179.

Zhang, Z., Du, J., Wang, S., Shao, L., Jin, K., Li, F., ... & Zhang, L. (2019). OTUB2 promotes cancer metastasis via hippo-independent activation of YAP and TAZ. Molecular cell, 73(1), 7-21.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-OTUB2 Recombinant Antibody (CBT3143)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry