OTUB2

Otubain 2 (OTUB2) is a member of DUBs that belong to the ovarian tumour (OTU) superfamily of proteins which consists of a five-stranded β-sheet sandwiched in between a small helical amino-terminal region consisting of α1 and α2, and a large helical region comprised of α3-α10. Like other DUBs, otubain 2 (OTUB2) cleaves proteins precisely at the ubiquitin-protein bond so that ubiquitylation process can be reversed and regulated. Otubain 2 (OTUB2)s active-site cleft is sterically occluded by a novel loop conformation resulting in an oxyanion hole, which consists uniquely of backbone amides. Furthermore, the residues that orient and stabilize the active-site histidine of otubain 2 (OTUB2) are different from other cysteine proteases. This reorganization of the active-site topology provides a possible explanation for the low turnover and substrate specificity of the otubains.
Full Name
OTUB2
Function
Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.
Biological Process
Negative regulation of double-strand break repairManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of histone H2A K63-linked ubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Protein deubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Protein K11-linked deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Protein K48-linked deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Protein K63-linked deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
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Anti-OTUB2 antibodies

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Rabbit Anti-OTUB2 Recombinant Antibody (CBXO-0465) (CBMAB-O0723-CQ)

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Target: OTUB2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXO-0465
Application*: E, IF
Datasheet SDS

Mouse Anti-OTUB2 Recombinant Antibody (CBXO-0208) (CBMAB-O0722-CQ)

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Target: OTUB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Monkey, Rat
Clone: CBXO-0208
Application*: F, WB
Datasheet SDS

Mouse Anti-OTUB2 Recombinant Antibody (2F6) (CBMAB-O0721-CQ)

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Target: OTUB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2F6
Application*: IF, WB
Datasheet SDS

Mouse Anti-OTUB2 Recombinant Antibody (2E5) (CBMAB-O0720-CQ)

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Target: OTUB2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2E5
Application*: F, WB
Datasheet SDS

Mouse Anti-OTUB2 Recombinant Antibody (CBXO-0207) (CBMAB-O0716-CQ)

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Target: OTUB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXO-0207
Application*: F, WB
Datasheet SDS

Mouse Anti-OTUB2 Recombinant Antibody (6F7) (CBMAB-O0715-CQ)

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Target: OTUB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6F7
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-OTUB2 (AA 126-235) Recombinant Antibody (2E7) (CBMAB-O0714-CQ)

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Target: OTUB2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E7
Application*: E, IP
Datasheet SDS

Mouse Anti-OTUB2 Recombinant Antibody (CBXO-0092) (CBMAB-O0700-CQ)

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Target: OTUB2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXO-0092
Application*: SE, IP, E
Datasheet SDS

Mouse Anti-OTUB2 Antibody (9BA30) (CBMAB-1477CQ)

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Target: OTUB2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 9BA30
Application*: E, WB
Datasheet SDS

Mouse Anti-OTUB2 Recombinant Antibody (CBT3143) (V2LY-0625-LY1844)

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Target: OTUB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3143
Application*: WB, F
Datasheet SDS

Mouse Anti-OTUB2 Recombinant Antibody (CBT3463) (V2LY-0625-LY1843)

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Target: OTUB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3463
Application*: IC, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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