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Mouse Anti-PAWR Recombinant Antibody (CBT2683) (V2LY-0625-LY2233)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2683
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Purified recombinant fragment of PAR4(aa1-330) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
PAWR
Entrez Gene ID
5074
UniProt ID
Q96IZ0
Function
Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
Biological Process
Actin filament bundle assemblyISS:UniProtKB
Apoptotic processISS:UniProtKB
Apoptotic signaling pathwayIEA:Ensembl
Negative regulation of B cell proliferationIEA:Ensembl
Negative regulation of fibroblast proliferationIEA:Ensembl
Negative regulation of gene expressionIEA:Ensembl
Negative regulation of T cell proliferationIEA:Ensembl
Negative regulation of T cell receptor signaling pathwayIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of amyloid precursor protein biosynthetic processIEA:Ensembl
Positive regulation of apoptotic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cellular senescenceIEA:Ensembl
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of hydrogen peroxide-mediated programmed cell deathIEA:Ensembl
Cellular Location
Cytoplasm
Nucleus
Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity).
Nuclear localization includes nucleoplasm and PML nuclear bodies.
PTM
Preferentially phosphorylated at the Thr-163 by PKC in cancer cells.
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For research use only. Not intended for any clinical use.

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