Rabbit Anti-PAX8 Recombinant Antibody (D2S2I) (CBMAB-CP1878-LY)

Rabbit

Human, Monkey, Rat

D2S2I

IgG

WB, IP, IF (ICC), CIP

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly274 of human PAX8 protein.

Human, Monkey, Rat

IgG

Monoclonal

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Liquid

100 µg/ml BSA, 50% glycerol

0.02% sodium azide

> 95% Purity determined by SDS-PAGE.

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]

Paired Box 8; Paired Box Gene 8;

Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.

Anatomical structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Anatomical structure morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Branching involved in ureteric bud morphogenesisManual Assertion Based On ExperimentIEP:UniProtKB
Cellular response to gonadotropin stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Central nervous system developmentManual Assertion Based On ExperimentIEP:UniProtKB
Inner ear morphogenesisISS:UniProtKB
Kidney developmentManual Assertion Based On ExperimentIEP:UniProtKB
Mesenchymal to epithelial transition involved in metanephros morphogenesisManual Assertion Based On ExperimentIEP:UniProtKB
Mesonephros developmentISS:UniProtKB
Metanephric comma-shaped body morphogenesisManual Assertion Based On ExperimentIEP:UniProtKB
Metanephric distal convoluted tubule developmentISS:UniProtKB
Metanephric epithelium developmentManual Assertion Based On ExperimentIEP:UniProtKB
Metanephric nephron tubule formationISS:UniProtKB
Metanephric S-shaped body morphogenesisManual Assertion Based On ExperimentIEP:UniProtKB
Negative regulation of apoptotic process involved in metanephric collecting duct developmentISS:UniProtKB
Negative regulation of apoptotic process involved in metanephric nephron tubule developmentISS:UniProtKB
Negative regulation of cardiac muscle cell apoptotic processIEA:Ensembl
Negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesisISS:UniProtKB
Negative regulation of mesenchymal cell apoptotic process involved in metanephros developmentISS:UniProtKB
Otic vesicle developmentManual Assertion Based On ExperimentIEP:UniProtKB
Positive regulation of branching involved in ureteric bud morphogenesisISS:UniProtKB
Positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisISS:UniProtKB
Positive regulation of metanephric DCT cell differentiationISS:UniProtKB
Positive regulation of thyroid hormone generationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Pronephric field specificationISS:UniProtKB
Pronephros developmentISS:UniProtKB
Regulation of apoptotic processISS:UniProtKB
Regulation of metanephric nephron tubule epithelial cell differentiationISS:UniProtKB
Regulation of thyroid-stimulating hormone secretionManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Sulfur compound metabolic processIEA:Ensembl
Thyroid gland developmentManual Assertion Based On ExperimentIMP:UniProtKB
Transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Urogenital system developmentISS:UniProtKB
Ventricular septum developmentIEA:Ensembl

Nucleus

Hypothyroidism, congenital, non-goitrous, 2 (CHNG2):
A disease characterized by thyroid dysgenesis, the most frequent cause of congenital hypothyroidism, accounting for 85% of case. The thyroid gland can be completely absent (athyreosis), ectopically located and/or severely hypoplastic. Ectopic thyroid gland is the most frequent malformation, with thyroid tissue being found most often at the base of the tongue.