Mouse Anti-PLCD3 Recombinant Antibody (E-5) (CBMAB-P2052-YC)

Name: Mouse Anti-PLCD3 Recombinant Antibody (E-5)
SKU: CBMAB-P2052-YC
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

E-5

Application

WB, IP, IF, ELISA

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Phospholipase C delta 3

Introduction

PLCD3 is a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations.

Entrez Gene ID

Human	113026
Mouse	72469
Rat	287745

UniProt ID

Human	Q8N3E9
Mouse	Q8K2J0
Rat	D4A978

Alternative Names

PLC-delta-3

Function

Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca2+ from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow (PubMed:10336610).
Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (By similarity).

Biological Process

AngiogenesisIEA:Ensembl
Labyrinthine layer blood vessel developmentIEA:Ensembl
Lipid catabolic processIEA:UniProtKB-KW
Phosphatidylinositol-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell population proliferationIEA:Ensembl

Cellular Location

Membrane
Cytoplasm
Cleavage furrow
Localizes at the cleavage furrow during cytokinesis.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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