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Mouse Anti-PLCD3 Recombinant Antibody (E-5) (CBMAB-P2052-YC)

Provided herein is a Mouse monoclonal antibody against Human Phospholipase C delta 3. The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all PLCD3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
E-5
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Phospholipase C delta 3
Introduction
PLCD3 is a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations.
Entrez Gene ID
Human113026
Mouse72469
Rat287745
UniProt ID
HumanQ8N3E9
MouseQ8K2J0
RatD4A978
Alternative Names
PLC-delta-3
Function
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca2+ from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow (PubMed:10336610).
Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (By similarity).
Biological Process
AngiogenesisIEA:Ensembl
Labyrinthine layer blood vessel developmentIEA:Ensembl
Lipid catabolic processIEA:UniProtKB-KW
Phosphatidylinositol-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell population proliferationIEA:Ensembl
Cellular Location
Membrane
Cytoplasm
Cleavage furrow
Localizes at the cleavage furrow during cytokinesis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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