PLCD3

PLCD3 is a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations.

Full Name

Phospholipase C delta 3

Function

Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca2+ from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow (PubMed:10336610).
Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (By similarity).

Biological Process

AngiogenesisIEA:Ensembl
Labyrinthine layer blood vessel developmentIEA:Ensembl
Lipid catabolic processIEA:UniProtKB-KW
Phosphatidylinositol-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell population proliferationIEA:Ensembl

Cellular Location

Membrane
Cytoplasm
Cleavage furrow
Localizes at the cleavage furrow during cytokinesis.