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Rabbit Anti-PPM1D Recombinant Antibody (D4F7) (CBMAB-CP2058-LY)

The product is antibody recognizes PPM1D. The antibody D4F7 immunoassay techniques such as: WB.
See all PPM1D antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D4F7
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly240 of human WIP1 protein.
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
protein phosphatase 1D magnesium-dependent, delta isoform
Entrez Gene ID
Human8493
Mouse53892
Rat287585
Monkey713045
UniProt ID
HumanO15297
MouseQ9QZ67
RatB1WCA0
MonkeyI0FVT7
Function
Involved in the negative regulation of p53 expression (PubMed:23242139).
Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed:15870257, PubMed:16311512).
Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629).
Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity).
Biological Process
Cellular response to starvationIEA:Ensembl
DNA damage response, signal transduction by p53 class mediatorIEA:Ensembl
DNA methylationISS:UniProtKB
G2/M transition of mitotic cell cycleIEA:Ensembl
Heterochromatin assemblyISS:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of gene expression, epigeneticManual Assertion Based On ExperimentIMP:UniProtKB
Peptidyl-threonine dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Regulation of transcription initiation from RNA polymerase II promoterTAS:Reactome
Response to bacteriumIEA:Ensembl
Response to radiationManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
Cytoplasm, cytosol
Involvement in disease
Jansen-de Vries syndrome (JDVS):
An autosomal dominant neurodevelopmental disorder characterized by mild to severe intellectual disability, psychomotor developmental delay, speech delay, and behavioral manifestations including attention deficit-hyperactivity disorder, autism and anxiety disorders. Most patients have variable additional features, including feeding and gastrointestinal difficulties, high pain threshold, hypersensitivity to sound, hypotonia, broad-based gait, and dysmorphic features, including mild facial abnormalities, strabismus, and small hands and feet.
Breast cancer (BC):
A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.
Ovarian cancer (OC):
The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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