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Mouse Anti-PPM1D Recombinant Antibody (4D1) (CBMAB-P2558-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein Phosphatase, Mg2+/Mn2+ Dependent 1D. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PPM1D antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4D1
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
PPM1D AA 496-605 partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein phosphatase 1D magnesium-dependent, delta isoform
Introduction
PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent 1D) is a protein coding gene. Diseases associated with PPM1D include Intellectual Developmental Disorder With Gastrointestinal Difficulties And High Pain Threshold and Breast Cancer. Among its related pathways are Development Dopamine D2 receptor transactivation of EGFR and Regulation of CFTR activity (norm and CF). Gene Ontology annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of the gene isPPM1G.
Entrez Gene ID
UniProt ID
Alternative Names
WIP1; PP2C-DELTA
Function
Involved in the negative regulation of p53 expression (PubMed:23242139).
Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed:15870257, PubMed:16311512).
Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629).
Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity).
Biological Process
Cellular response to starvationIEA:Ensembl
DNA damage response, signal transduction by p53 class mediatorIEA:Ensembl
DNA methylationISS:UniProtKB
G2/M transition of mitotic cell cycleIEA:Ensembl
Heterochromatin assemblyISS:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of gene expression, epigeneticManual Assertion Based On ExperimentIMP:UniProtKB
Peptidyl-threonine dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Regulation of transcription initiation from RNA polymerase II promoterTAS:Reactome
Response to bacteriumIEA:Ensembl
Response to radiationManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
Cytoplasm, cytosol
Involvement in disease
Jansen-de Vries syndrome (JDVS):
An autosomal dominant neurodevelopmental disorder characterized by mild to severe intellectual disability, psychomotor developmental delay, speech delay, and behavioral manifestations including attention deficit-hyperactivity disorder, autism and anxiety disorders. Most patients have variable additional features, including feeding and gastrointestinal difficulties, high pain threshold, hypersensitivity to sound, hypotonia, broad-based gait, and dysmorphic features, including mild facial abnormalities, strabismus, and small hands and feet.
Breast cancer (BC):
A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.
Ovarian cancer (OC):
The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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