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Rabbit Anti-PPP1R10 Recombinant Antibody (EPR11706) (CBMAB-1683-CN)

This product is a rabbit antibody that recognizes PPP1R10 of human. The antibody EPR11706 can be used for immunoassay techniques such as: IF, IHC-P, WB.
See all PPP1R10 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EPR11706
Antibody Isotype
IgG
Application
IF, IHC-P, WB

Basic Information

Immunogen
Synthetic peptide within Human PPP1R10 aa. 550-650 (Cysteine residue).
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
49% PBS, 50% Glycerol, 0.05% BSA, pH 7.2
Preservative
0.01% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PPP1R10
Introduction
This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity).
Entrez Gene ID
5514
UniProt ID
Q96QC0
Alternative Names
p99; FB19; R111; CAT53; PNUTS; PP1R10
Function
Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity).
Biological Process
Negative regulation of cardiac muscle cell apoptotic processManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of mitotic DNA damage checkpointManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of telomere maintenanceManual Assertion Based On ExperimentIMP:BHF-UCL
Protein import into nucleusManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
Found in discrete nucleoplasmic bodies and within nucleoli. Associates with chromatin during interphase, excluded from condensed chromosomes during early mitosis and is reloaded onto chromosomes at the late telophase (By similarity).
PTM
Phosphorylated on Ser-398 by PKA within the region necessary for interaction with PPP1CA.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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