PPP1R10

This gene encodes a protein with similarity to a rat protein that has an inhibitory effect on protein phosphatase-1 (PP1). The rat protein localizes to the nucleus and colocalizes with chromatin at distinct phases during mitosis. This gene lies within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq]

Full Name

PPP1R10

Function

Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity).

Biological Process

Negative regulation of cardiac muscle cell apoptotic processManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of mitotic DNA damage checkpointManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of telomere maintenanceManual Assertion Based On ExperimentIMP:BHF-UCL
Protein import into nucleusManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Nucleus
Found in discrete nucleoplasmic bodies and within nucleoli. Associates with chromatin during interphase, excluded from condensed chromosomes during early mitosis and is reloaded onto chromosomes at the late telophase (By similarity).

PTM

Phosphorylated on Ser-398 by PKA within the region necessary for interaction with PPP1CA.