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Mouse Anti-PPP1R10 Recombinant Antibody (47/PNUTS) (CBMAB-P2594-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein Phosphatase 1 Regulatory Subunit 10. The antibody can be used for immunoassay techniques, such as WB, IF.
See all PPP1R10 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat, Mouse
Clone
47/PNUTS
Antibody Isotype
IgG1
Application
WB, IF

Basic Information

Immunogen
Rat PNUTS, AA 605-716
Specificity
Human, Rat, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PPP1R10
Introduction
PPP1R10 is a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1.
Entrez Gene ID
Human5514
Mouse52040
Rat65045
UniProt ID
HumanQ96QC0
MouseQ80W00
RatO55000
Alternative Names
Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 10; CAT53; PNUTS; FB19
Function
Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity).
Biological Process
Negative regulation of cardiac muscle cell apoptotic processManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of mitotic DNA damage checkpointManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of telomere maintenanceManual Assertion Based On ExperimentIMP:BHF-UCL
Protein import into nucleusManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
Found in discrete nucleoplasmic bodies and within nucleoli. Associates with chromatin during interphase, excluded from condensed chromosomes during early mitosis and is reloaded onto chromosomes at the late telophase (By similarity).
PTM
Phosphorylated on Ser-398 by PKA within the region necessary for interaction with PPP1CA.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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