Mouse Anti-PPP1R10 Recombinant Antibody (1D6) (CBMAB-P2593-YC)

Name: Mouse Anti-PPP1R10 Recombinant Antibody (1D6)
SKU: CBMAB-P2593-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1D6

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid in PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

PPP1R10

Introduction

PPP1R10 is a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1.

Entrez Gene ID

5514

UniProt ID

Q96QC0

Alternative Names

Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 10; CAT53; PNUTS; FB19

Function

Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity).

Biological Process

Negative regulation of cardiac muscle cell apoptotic processManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of mitotic DNA damage checkpointManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of telomere maintenanceManual Assertion Based On ExperimentIMP:BHF-UCL
Protein import into nucleusManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Nucleus
Found in discrete nucleoplasmic bodies and within nucleoli. Associates with chromatin during interphase, excluded from condensed chromosomes during early mitosis and is reloaded onto chromosomes at the late telophase (By similarity).

PTM

Phosphorylated on Ser-398 by PKA within the region necessary for interaction with PPP1CA.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-PPP1R10 Antibody (1G12) (CAT#: CBMAB-0847-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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