Mouse Anti-PTPN4 Recombinant Antibody (3C8) (CBMAB-P3438-YC)

Name: Mouse Anti-PTPN4 Recombinant Antibody (3C8)
SKU: CBMAB-P3438-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

3C8

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG3, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)

Introduction

PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation.

Entrez Gene ID

5775

UniProt ID

P29074

Alternative Names

MEG; PTPMEG; PTPMEG1

Function

Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis (PubMed:25825441, PubMed:27246854).
Regulates neuronal cell homeostasis by protecting neurons against apoptosis (PubMed:20086240).
Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction (PubMed:25825441).
Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway (By similarity).
May act at junctions between the membrane and the cytoskeleton.

Biological Process

Peptidyl-tyrosine phosphorylationIEA:Ensembl
Protein dephosphorylationManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cell membrane
Cytoplasm, cytoskeleton
Cytoplasm

PTM

Highly phosphorylated on serine and threonine residues but not on tyrosines.
Cleaved and activated by calpain I/CAPN1.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-PTPN4 Recombinant Antibody (2C8) (CAT#: CBMAB-A7224-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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