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Mouse Anti-PTPN4 Recombinant Antibody (3C8) (CBMAB-P3438-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein tyrosine phosphatase, non-receptor type 4. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PTPN4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3C8
Antibody Isotype
IgG3, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG3, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
Introduction
PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation.
Entrez Gene ID
5775
UniProt ID
P29074
Alternative Names
MEG; PTPMEG; PTPMEG1
Function
Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis (PubMed:25825441, PubMed:27246854).
Regulates neuronal cell homeostasis by protecting neurons against apoptosis (PubMed:20086240).
Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction (PubMed:25825441).
Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway (By similarity).
May act at junctions between the membrane and the cytoskeleton.
Biological Process
Peptidyl-tyrosine phosphorylationIEA:Ensembl
Protein dephosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Cytoplasm, cytoskeleton
Cytoplasm
PTM
Highly phosphorylated on serine and threonine residues but not on tyrosines.
Cleaved and activated by calpain I/CAPN1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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