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Mouse Anti-PTPRD Recombinant Antibody (CBT2992) (V2LY-0625-LY997)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2992
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human PTPRD (AA: extra 1077-1265) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
protein tyrosine phosphatase receptor type D
Entrez Gene ID
5789
UniProt ID
P23468
Research Area
Neuroscience,Signal transduction
Function
Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2.
Biological Process
Cell surface receptor protein tyrosine phosphatase signaling pathway
Cellular response to hypoxia
Cellular response to platelet-derived growth factor stimulus
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
Modulation of chemical synaptic transmission
Negative regulation of receptor signaling pathway via JAK-STAT
Neuron differentiation
Phosphate-containing compound metabolic process
Positive regulation of dendritic spine morphogenesis
Positive regulation of synapse assembly
Presynapse assembly
Presynaptic membrane assembly
Regulation of immune response
Regulation of postsynaptic density assembly
Signal transduction
Synaptic membrane adhesion
Trans-synaptic signaling by trans-synaptic complex
Cellular Location
Membrane ; Single-pass type I membrane protein
Topology
Extracellular: 21-1265
Helical: 1266-1290
Cytoplasmic: 1291-1912
PTM
A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization.
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For research use only. Not intended for any clinical use.

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