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Mouse Anti-RAB4A Recombinant Antibody (CBCNR-051) (CBMAB-R0893-CN)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Monkey
Clone
CBCNR-051
Antibody Isotype
IgG
Application
ELISA, WB, IHC-P, FC

Basic Information

Immunogen
Purified recombinant fragment of human RAB4A
Specificity
Human, Mouse, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, without Mg2+, Ca2+, pH 7.4, 0.15M NaCl, 50% Glycerol
Preservative
0.02% Sodium azide

Target

Full Name
RAB4A, member RAS oncogene family
Introduction
This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
Entrez Gene ID
Human5867
Mouse19341
Monkey694288
UniProt ID
HumanP20338
MouseP56371
MonkeyA0A1D5QP18
Alternative Names
RAB4A, Member RAS Oncogene Family; RAB4; HTLV-1 Related Endogenous Sequence; Ras-Related Protein Rab-4A; HRES-1/RAB4; HRES-1; HRES1;
Function
Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (PubMed:15907487, PubMed:16034420).
Involved in protein transport (PubMed:29425100).
Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (PubMed:29425100).
Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity).
Biological Process
Biological Process antigen processing and presentationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein transportIEA:UniProtKB-KW
Biological Process Rab protein signal transductionIEA:InterPro
Biological Process regulation of endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Cytoplasm
Early endosome membrane
Recycling endosome membrane
Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1.
PTM
Phosphorylated by CDK1 kinase during mitosis.
Serotonylation of Gln-72 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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