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RAB4A

This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene.

Full Name

RAB4A, member RAS oncogene family

Function

Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (PubMed:15907487, PubMed:16034420).
Involved in protein transport (PubMed:29425100).
Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (PubMed:29425100).
Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity).

Biological Process

Biological Process antigen processing and presentationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein transportIEA:UniProtKB-KW
Biological Process Rab protein signal transductionIEA:InterPro
Biological Process regulation of endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane
Cytoplasm
Early endosome membrane
Recycling endosome membrane
Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1.

PTM

Phosphorylated by CDK1 kinase during mitosis.
Serotonylation of Gln-72 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity.

Anti-RAB4A antibodies

Mouse Anti-RAB4A Recombinant Antibody (2H11-H9-D6) (CBMAB-Z0402-LY)

SDS

Target: RAB4A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Monkey

Clone: 2H11-H9-D6

Application*: WB, IH, F

Rabbit Anti-RAB4A Recombinant Antibody (CBCNR-045) (CBMAB-R0013-CN)

SDS

Target: RAB4A

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBCNR-045

Application*: WB, F, IF

Rabbit Anti-RAB4A Recombinant Antibody (CBCNR-046) (CBMAB-R0014-CN)

SDS

Target: RAB4A

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBCNR-046

Application*: WB, IP, IF

Mouse Anti-RAB4A Recombinant Antibody (13B664) (CBMAB-R0884-CN)

SDS

Target: RAB4A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey, Mouse

Clone: 13B664

Application*: E

Mouse Anti-RAB4A Recombinant Antibody (15B237) (CBMAB-R0885-CN)

SDS

Target: RAB4A

Host: Mouse

Specificity: Human, Mouse, Rat

Clone: 15B237

Application*: ICC, WB

Mouse Anti-RAB4A Recombinant Antibody (1C10) (CBMAB-R0886-CN)

SDS

Target: RAB4A

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1C10

Application*: E, WB

Mouse Anti-RAB4A Recombinant Antibody (3D1-A10-D11) (CBMAB-R0888-CN)

SDS

Target: RAB4A

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: 3D1-A10-D11

Application*: IF, WB

Mouse Anti-RAB4A Recombinant Antibody (3D1-A9-H10) (CBMAB-R0889-CN)

SDS

Target: RAB4A

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat, Monkey

Clone: 3D1-A9-H10

Application*: WB

Mouse Anti-RAB4A Recombinant Antibody (4E11) (CBMAB-R0890-CN)

SDS

Target: RAB4A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: 4E11

Application*: F, IH, WB

Mouse Anti-RAB4A Recombinant Antibody (7/Rab4) (CBMAB-R0891-CN)

SDS

Target: RAB4A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat, Dog, Human, Mouse

Clone: 7/Rab4

Application*: WB, IF

Mouse Anti-RAB4A Recombinant Antibody (CBCNR-047) (CBMAB-R0892-CN)

SDS

Target: RAB4A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBCNR-047

Application*: WB

Mouse Anti-RAB4A Recombinant Antibody (CBCNR-051) (CBMAB-R0893-CN)

SDS

Target: RAB4A

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Monkey

Clone: CBCNR-051

Application*: E, WB, P, F

Rabbit Anti-RAB4A Recombinant Antibody (CBCNR-052) (CBMAB-R0894-CN)

SDS

Target: RAB4A

Host: Rabbit

Specificity: Human, Mouse, Rat

Clone: CBCNR-052

Application*: WB, IF, IP

Rabbit Anti-RAB4A Recombinant Antibody (CBCNR-053) (CBMAB-R0895-CN)

SDS

Target: RAB4A

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBCNR-053

Application*: WB, IF, IP

Mouse Anti-RAB4A Recombinant Antibody (E-10) (CBMAB-R0896-CN)

SDS

Target: RAB4A

Host: Mouse

Specificity: Mouse, Rat, Human

Clone: E-10

Application*: WB, IP, IF, E

Mouse Anti-RAB4A Recombinant Antibody (M80561) (CBMAB-R0897-CN)

SDS

Target: RAB4A

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: M80561

Application*: WB, ICC

Recombinant Rabbit Anti-RAB4A Antibody (CBAb205) (CBMAB-Ab205-LY)

SDS

Target: RAB4A

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBAb205

Application*: WB, IF, IP

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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