RAB4A

This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene.
Full Name
RAB4A, member RAS oncogene family
Function
Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (PubMed:15907487, PubMed:16034420).
Involved in protein transport (PubMed:29425100).
Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (PubMed:29425100).
Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity).
Biological Process
Biological Process antigen processing and presentationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein transportIEA:UniProtKB-KW
Biological Process Rab protein signal transductionIEA:InterPro
Biological Process regulation of endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Cytoplasm
Early endosome membrane
Recycling endosome membrane
Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1.
PTM
Phosphorylated by CDK1 kinase during mitosis.
Serotonylation of Gln-72 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity.
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Anti-RAB4A antibodies

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Recombinant Rabbit Anti-RAB4A Antibody (CBAb205) (CBMAB-Ab205-LY)

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Target: RAB4A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBAb205
Application*: WB, IF, IP
Datasheet SDS

Mouse Anti-RAB4A Recombinant Antibody (2H11-H9-D6) (CBMAB-Z0402-LY)

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Target: RAB4A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey
Clone: 2H11-H9-D6
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-RAB4A Recombinant Antibody (M80561) (CBMAB-R0897-CN)

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Target: RAB4A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: M80561
Application*: WB, ICC
Datasheet SDS

Mouse Anti-RAB4A Recombinant Antibody (E-10) (CBMAB-R0896-CN)

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Target: RAB4A
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: E-10
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-RAB4A Recombinant Antibody (CBCNR-053) (CBMAB-R0895-CN)

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Target: RAB4A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBCNR-053
Application*: WB, IF, IP
Datasheet SDS

Rabbit Anti-RAB4A Recombinant Antibody (CBCNR-052) (CBMAB-R0894-CN)

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Target: RAB4A
Host: Rabbit
Specificity: Human, Mouse, Rat
Clone: CBCNR-052
Application*: WB, IF, IP
Datasheet SDS

Mouse Anti-RAB4A Recombinant Antibody (CBCNR-051) (CBMAB-R0893-CN)

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Target: RAB4A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey
Clone: CBCNR-051
Application*: E, WB, P, F
Datasheet SDS

Mouse Anti-RAB4A Recombinant Antibody (CBCNR-047) (CBMAB-R0892-CN)

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Target: RAB4A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNR-047
Application*: WB
Datasheet SDS

Mouse Anti-RAB4A Recombinant Antibody (7/Rab4) (CBMAB-R0891-CN)

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Target: RAB4A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Dog, Human, Mouse
Clone: 7/Rab4
Application*: WB, IF
Datasheet SDS

Mouse Anti-RAB4A Recombinant Antibody (4E11) (CBMAB-R0890-CN)

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Target: RAB4A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 4E11
Application*: F, IH, WB
Datasheet SDS

Mouse Anti-RAB4A Recombinant Antibody (3D1-A9-H10) (CBMAB-R0889-CN)

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Target: RAB4A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat, Monkey
Clone: 3D1-A9-H10
Application*: WB
Datasheet SDS

Mouse Anti-RAB4A Recombinant Antibody (3D1-A10-D11) (CBMAB-R0888-CN)

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Target: RAB4A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: 3D1-A10-D11
Application*: IF, WB
Datasheet SDS

Mouse Anti-RAB4A Recombinant Antibody (1C10) (CBMAB-R0886-CN)

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Target: RAB4A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1C10
Application*: E, WB
Datasheet SDS

Mouse Anti-RAB4A Recombinant Antibody (15B237) (CBMAB-R0885-CN)

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Target: RAB4A
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: 15B237
Application*: ICC, WB
Datasheet SDS

Mouse Anti-RAB4A Recombinant Antibody (13B664) (CBMAB-R0884-CN)

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Target: RAB4A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Mouse
Clone: 13B664
Application*: E
Datasheet SDS

Rabbit Anti-RAB4A Recombinant Antibody (CBCNR-046) (CBMAB-R0014-CN)

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Target: RAB4A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBCNR-046
Application*: WB, IP, IF
Datasheet SDS

Rabbit Anti-RAB4A Recombinant Antibody (CBCNR-045) (CBMAB-R0013-CN)

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Target: RAB4A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBCNR-045
Application*: WB, F, IF
Datasheet SDS

Mouse Anti-RAB4A Recombinant Antibody (CBT3376) (V2LY-0625-LY2758)

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Target: RAB4A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey
Clone: CBT3376
Application*: WB, IH, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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